GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：2,3-Dichloro-1-propanol
CAS：616-23-9
Result：
| ID: | 21A3533 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid at room temperature (HSDB (2003)) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid at room temperature (HSDB (2003)) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid at room temperature (HSDB (2003)) |
| 6 | Flammable liquids | Category 4 | - | Warning | H227: Combustible liquid |
P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Classified into Category 4 since flash point 91degC (Ullmanns (E) (6th, 2003)) is >60 degC and <=93 degC. |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid at room temperature (HSDB (2003)) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Classification not possible | - | - | - | - | No data available. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid at room temperature (HSDB (2003)) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid at room temperature (HSDB (2003)) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on a LD50 value of 90 mg/kg for rats (HSDB (2003)), the substance was classified into Category 3. |
| 1 | Acute toxicity （Dermal） | Category 2 |
|
Danger | H310: Fatal in contact with skin |
P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the LD50 value of 200 mg/kg for rabbits (HSDB (2003)), the substance was classified into Category 2. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid at room temperature (HSDB (2003)) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | There is only report of skin irritant (HSDB (2003)). Therefore, classification is not possible due to lack of information. |
| 3 | Serious eye damage/eye irritation | Category 2A |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Based on a report that scale of irritation was 5 (max. 10) in a rabbit test and a report of severe eye irritant (HSDB (2003)), the substance was classified into Category 2A. As relevant information, there is a report of "severe irritating" in another rabbit test (RTECS (2003)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there is a report of a positive Ames test (NTP DB (access on Aug. 2009)). The substance is an existing chemical substance for which mutagenicity was established under the provisions of Article 57-3 of the Industrial Safety and Health Law. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (liver) |
|
Warning | H371: May cause damage to organs (liver) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... |
Two middle aged men developed severe hepatic injury just after cleaning a tank at a plant producing dichloropropanol and died from hepatic failure 4 and 11 days, respectively, following exposure. Liver specimens taken at autopsy showed submassive hepatic necrosis (HSDB (2003)). This information is reported in a document in List 2. The substance was classified into Category 2 (liver). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (heart, liver) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (heart, liver) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
In a rat test by oral administration for 91 to 92 days, myocardial degeneration was observed at the 35 and 100 mg/kg/day dose levels. Additionally, hypertrophy, karyomegaly and bile duct proliferations in the liver were observed at the 100 mg/kg/day dose level and serum enzyme changes were seen at the 35 and 100 mg/kg/day dose levels (IRIS (2004)). Since these effects on the heart and liver are observed at dose levels within the guidance value range for Category 2,the substance was classified into Category 2 (heart, liver). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |