GHS Classification Result

Chemical Name:1,1,1-Trifluoroethane
CAS:420-46-2

Result:
ID: 21A3536
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Gas (GHS definition)
2 Flammable gases (including chemically unstable gases) Category 1 Danger H220: Extremely flammable gas P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P381: Eliminate all ignition sources if safe to do so.
P403: Store in a well-ventilated place.
The gaseous mixture with air of 13vol% or lower concentrations is combustible (the explosive range: 4.5 - 19 vol% (Hommel (1996)), further the mixture is classified into Division 2.1 in UNRTDG (UN2035).
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not classified - - - - Flammable gas Division 2.1 in UNRTDG (UN2035)
5 Gases under pressure Low pressure liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. Critical temperature is 73.6 degC (Ullmanns (E) (6th, 2003)) exceeding 65 degC.
6 Flammable liquids Not applicable - - - - Gas (GHS definition)
7 Flammable solids Not applicable - - - - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Gas (GHS definition)
9 Pyrophoric liquids Not applicable - - - - Gas (GHS definition)
10 Pyrophoric solids Not applicable - - - - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable - - - - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Gas (GHS definition)
13 Oxidizing liquids Not applicable - - - - Gas (GHS definition)
14 Oxidizing solids Not applicable - - - - Gas (GHS definition)
15 Organic peroxides Not applicable - - - - Gas (GHS definition)
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - No data available.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not classified - - - - Based on LC50 values of >540000 ppm/4h and >600000 ppm/4h for rats (ECETOC JACC 52 (2006)), the substance was classified as "Not classified".
1 Acute toxicity (Inhalation: Vapours) Not applicable - - - - Gas (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Not applicable - - - - Gas (GHS definition)
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - Based on negative result in inhalation mouse bone marrow micronucleus test (in vivo somatic cell mutagenicity tests) (ECETOC JACC No.52 (2006)), the substance was classified as "Not classified". As relevant information, from in vitro testing, negative results were reported in all Ames tests except for one test using TA100 and TA1535 in which a positive result was reported (ECETOC JACC No.52 (2006)). In addition, there are reports of negative results for human lymphocyte chromosomal aberration tests and cell transformation test with hamster kidney fibroblasts (ECETOC JACC No.52 (2006)).
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data. However, there is a report that no test substance related neoplastic or non-neoplastic lesions were observed following oral administration for 52 weeks and observation for an additional 73 weeks. This was a limited test involving a small number of animals and only one dosage (ECETOC JACC 52 (2006)).
7 Reproductive toxicity Classification not possible - - - - Although there were no fetal developmental toxicity including teratogenicity in either rat or rabbit inhalation tests during organogenesis period (ECETOC JACC 52 (2006)), classification was not possible due to lack of data for sexual function and fertility of parental animals.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Based on results of a rat acute inhalation toxicity test (ECETOC JACC 52 (2006)) where no mortality or effects on clinical signs, necroscopic findings or organ weights were observed after 4-hour inhalation exposure at 540000 or 600000 ppm (exposure levels exceed the upper limit of the guidance value range), the substance corresponds to "Not classified" in regard to inhalation exposure. However, classification was not possible due to lack of data for other exposure routes.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a 4-week inhalation test in which rats were exposed to 2000 to 39000 ppm (90-day equivalent: 615 - 12,000 ppm), there were no significantly toxic effects except for degenerative changes in the testes which was attributable to confounding factors related to the method of exposure (ECETOC JACC 52 (2006)). In order to confirm the results, a second 4-week inhalation test focusing on histopathological examination of testes was carried out, with no effects on microscopic changes in the testes of exposed animals observed (ECETOC JACC 52 (2006)). Additionally, it was reported that NOAEL was considered to be 40,000 ppm in a rat 13-week inhalation test (ECETOC JACC 52 (2006)). Therefore, the substance corresponds to "Not classified" with inhalation exposure, but classification was not possible due to lack of data with other exposure routes.
10 Aspiration hazard Not applicable - - - - Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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