GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Chlorotrifluoroethylene
CAS：79-38-9
Result：
| ID: | 21A3544 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Flammable gases （including chemically unstable gases） | Category 1 |
|
Danger | H220: Extremely flammable gas |
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely. P381: Eliminate all ignition sources if safe to do so. P403: Store in a well-ventilated place. |
Classified into Division 2.3, Subsidiary risk 2.1 in UNRTDG (UN1082). |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not classified | - | - | - | - | The substance is classified into Division 2.3, Subsidiary risk 2.1 in UNRTDG (UN1082) and is flammable gas. |
| 5 | Gases under pressure | Low pressure liquefied gas |
|
Warning | H280: Contains gas under pressure; may explode if heated | P410+P403: Protect from sunlight. Store in a well-ventilated place. | Critical temperature is 105.8 degC (Ullmanns (E) (6th, 2003), Hommel (1996)), 106.2 degC (Weiss (2nd, 1986)) exceeding 65 degC. |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Gas (GHS definition) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Gas (GHS definition) |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to gaseous substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | Classification not possible due to lack of data. As relevant information, a LD50 value is 268 mg/kg for mice (RTECS (2006), original literature: Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. 21,377 (1968)) and the gas dissolved in a vehicle is administrated in this test. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Classification not possible | - | - | - | - | Classification not possible due to lack of data. As relevant information, a LC50 value of 1000 ppm/4h for rats (RTECS (2006)). |
| 1 | Acute toxicity （Inhalation: Vapours） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Although there is a report that in a inhalation exposure test with rats during gestation days 6 - 19, no embryotoxic, teratogenic, or fetotoxic effects were seen at a dose level where parental animals showed body weight gain reductions (HSDB (2003)), classification was not possible due to lack of data for sexual function and fertility of parental animals. |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (kidney) |
|
Warning | H371: May cause damage to organs (kidney) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... |
Within 2 days following 4-hour inhalation exposure at 100 - 540 ppm, rats exhibited dose-related proximal tubular necrosis, increases in urinary fluoride, urinary LDH activity, serum creatinine and BUN (HSDB (2003)). Since these effects are observed at dose levels within the guidance value range for Category 2, the substance was classified into Category 2 (kidney). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (kidney) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (kidney) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Rats inhaling 1097 - 1240 or 491 - 539 mg/m3 for 7 weeks (6 hr/day, 90-day equivalent: 104 - 118 ppm or 47 - 51 ppm) showed necrosis and degeneration in the kidney tubules (HSDB (2003)). Rats inhaling 241 ppm for 2 weeks (6 hr/day, 90-day equivalent: 37 ppm) showed signs of toxic nephrosis (HSDB (2003)). In a 13-week inhalation test by exposure to 29 - 121 ppm, dose related changes in biochemical indices and organ weights were observed. Additionally, histology revealed kidney toxicity and the middle portion of the kidney cortex showed large, usually dilated tubules lined by enlarged epithelial cells with enlarged nuclei (HSDB (2003)). Since these effects on the kidney are observed at dose levels within the guidance value range for Category 1 and are reported in a document in List 2, the substance was classified into Category 2 (kidney). |
| 10 | Aspiration hazard | Not applicable | - | - | - | - | Gas (GHS definition) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |