GHS Classification Result

Chemical Name：Ethyl vinyl ether
CAS：109-92-2

Result：
ID: 21A3548
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 1 Danger H224: Extremely flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified into Category 1 from flash point -45 degC (IUCLID (2000)) and initial boiling point 35 degC (Lange (16th, 2005). The substance is classified into Class 3, PG I in UNRTDG (UN1302).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Type G - - - - Classified into Type G since the substance added stabilizer (potassium hydroxide) is being distributed and is classified into Class 3, PG I in UNRTDG (UN1302) though there are chemical groups (unsaturated hydrocarbon) present in the molecule associated with self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 180 degC (IUCLID (2000)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to liquid (low boiling point) substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on a LD50 value of 8.16 mL/kg (6153 mg/kg) for rats (PATTY (5th, 2001)), the substance was classified into "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Based on a LD50 value of >20 mL/kg (>15000 mg/kg) for rabbits (PATTY (5th, 2001)), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - Based on the result of no mortality (0/6) in rats exposed at 64,000 ppm (vapour) for 4-hour (PATTY (5th, 2001)), the substance was classified as "Not classified". Since the vapour concentration was lower than 90% of saturated vapour pressure concentration (672,368 ppm), the substance was determined as "vapour with almost no included mists", and classification criteria for gas was adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Based on reports of grade 1 (maximum grade 10) irritation after open application to the skin of rabbits (PATTY (5th, 2001)), and not irritating in another rabbit test (OECD TG404), the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - Based on a report of "not irritating" in a rabbit test (OECD TG405) (IUCLID (2000)), the substance was classified as "Not classified".
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there is a report of a negative Ames test (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is a report that the substance concentration necessary to produce surgical anesthesia by inhalation is 6% (PATTY (5th, 2001)). An anesthesia effect was observed in 50 % of mice following exposure to substance vapour at a concentration of 108 mg/L for 15 min (IUCLID (2000)). No pathological changes in the liver and kidney were observed in rats at 2 weeks after 15-minute anaesthesia with the substance and no liver dysfunction was observed in dogs and monkeys after 60-minute anaesthesia with the substance (IUCLID (2000)). Since narcotic effects were observed without other toxic effects, the substance was classified into Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Classified into Not classified from its 96h-LC50 = 2200 - 4600 mg/L for fish (Golden orfe), 24h-EC50 >100 mg/L for Crustacea (Daphnia magna), 72h-EC50 = 510 mg/L for algae (Scenedesmus) (IUCLID, 2000 for any).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified into Not classified since its acute toxicity is Not classified and it is not non-water soluble (water solubility = 10000 mg/L (PHYSPROP Database, 2010)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information