GHS Classification Result

Chemical Name:Nitrogen trifluoride
CAS:7783-54-2

Result:
ID: 21A3572
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Gas (GHS definition)
2 Flammable gases (including chemically unstable gases) Not classified - - - - The substance is classified into Division 2.2, Subsidiary risk 5.1 in UNRTDG (UN2451) and is not flammable gas.
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Category 1 Danger H270: May cause or intensify fire; oxidizer P370+P376: In case of fire: Stop leak if safe to do so.
P220: Keep/Store away from clothing/.../combustible materials.
P244: Keep reduction valves free from grease and oil.
P403: Store in a well-ventilated place.
The substance is classified into Division 2.2, Subsidiary risk 5.1 in UNRTG (UN2451) and is oxidizing gas.
5 Gases under pressure High pressure liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. Critical temperature is -39.3 degC (HSDB (2009)) between -50 degC and 65 degC.
6 Flammable liquids Not applicable - - - - Gas (GHS definition)
7 Flammable solids Not applicable - - - - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Gas (GHS definition)
9 Pyrophoric liquids Not applicable - - - - Gas (GHS definition)
10 Pyrophoric solids Not applicable - - - - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable - - - - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Gas (GHS definition)
13 Oxidizing liquids Not applicable - - - - Gas (GHS definition)
14 Oxidizing solids Not applicable - - - - Gas (GHS definition)
15 Organic peroxides Not applicable - - - - Gas (GHS definition)
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - No data available.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Based on a LC50 value of 6700 ppm/1h (3350 ppm/4h) for rats (ACGIH (2001)), the substance was classified into Category 4.
1 Acute toxicity (Inhalation: Vapours) Not applicable - - - - Gas (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Not applicable - - - - Gas (GHS definition)
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (blood system) Warning H371: May cause damage to organs (blood system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
In a rat inhalation test, a substantial increase in circulating methemoglobin was detectable at 1000 ppm/4h, deaths occurred at 2500 ppm/4h and higher concentrations, and the methemoglobin concentrations at the time of death were equivalent to 60% to 70% of the total blood pigment (ACGIH (2001)). Additionally, it is reported that the substance cause anoxic deaths due to methemoglobinemia and results in pathologically enlargement and darkening of the spleen (ACGIH (2001)). There is a report that dogs exposure at 9600 ppm/60min exhibited Heinz body-induced hemolysis, anemia, decreased hematocrit, decreased hemoglobin, reduced red blood cell count, and clinical signs consistent with histotoxic anoxia as a result of methemoglobin formation (ACGIH (2001)). Since the major effects are induced by methemoglobin formation and are observed at dose levels within the guidance value range for Category 2, the substance was classified into Category 2 (blood system).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
It is reported that inhalation by rats at 100 ppm/7 hr/day (116 ppm/6 hr/day) for 19 weeks resulted in mild to moderate pathologic changes in liver and interstitial and tubular nephritis in kidneys and the characteristics of the renal injury suggested fluoride toxicosis. (ACGIH (2001)). Since the exposure level is within the guidance value range for Category 2, the substance was classified into Category 2 (liver, kidney). On the other hand, the exposure failed to cause significant effects on the spleen or on hematological parameters and there was no evidence of fluorosis in the teeth or bones (ACGIH (2001)).
10 Aspiration hazard Not applicable - - - - Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information