NITE - Chemical Management Field

GHS Classification Result

Chemical Name：Bromobenzene
CAS：108-86-1

Result：


ID:	21A3573
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2009
Reference Manual:	GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3		Warning	H226: Flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Classified into Category 3 since flash point 51 degC (closed-cup) (Hommel (1996)) is >=23 degC and <=60 degC. The substance is classified into Class 3, PG III in UNRTDG (UN2514).
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	-	-	-	-	Auto-ignition point is 565 degC (Chapman (Ver. 17.1, 2009)) exceeding 70 degC.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	Organic compounds containing no oxygen, fluorine or chlorine
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on a LD50 value of 2.7 g/kg for rats (PATTY (5th, 2001)), the substance was classified into "Not classified" in JIS Classification (corresponding to Category 5 in GHS classification).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Category 3		Danger	H331: Toxic if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on a LC50 value of 21,000 mg/m3/2h (2133 ppm/4h) for rats (PATTY (5th, 2001)), the substance was classified into Category 3. Since the report of the vapour was in the assessment document, the classification criteria for gas was adopted.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	Based on reports of irritating for the skin (PATTY (5th, 2001)) and irritant to skin (HSDB (2003)), and classification as Xi; R38 in EU classification (EU-Annex I (access on Aug. 2009)), the substance was classified into Category 2
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of a negative Ames test and a negative Chinese hamster ovary cells chromosomal aberration test (NTP DB (access on Aug. 2009)).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	It is noted that the substance shows biological activity (toxicity) through conversion by an oxidative metabolic process related to a metabolic enzyme in the liver and enhances the hepatotoxicity by induction of microsomal enzymes (PATTY (5th, 2001)). It is also reported that the metabolites can be found in the areas of hepatic centrilobular necrosis induced by the substance (HSDB (2003)). Rats orally administered at 3 g/kg showed widespread hepatic necrosis not only around centrilobular veins but also around all tributaries of the hepatic veins (HSDB (2003)). In addition, in an acute oral toxicity test with rats at levels of 2000 - 4000 mg/kg, clinical observations included lacrimation, chromodacryorrhea, stained perineal area, stained face, tremors, weakness, and lethargy (HSDB (2003)). Since these findings were observed at a dose level exceeding the guidance value range and effects at the approximate cut-off value are not clear due to lack of data, classification was not possible.
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, nervous system)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (liver, nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	It is reported that the substance shows biological activity (toxicity) through conversion by oxidative metabolic process related to metabolic enzyme in the liver and enhances the hepatotoxicity by induction of microsomal enzymes (PATTY (5th, 2001)). It is also reported that the metabolites can be found in the areas of hepatic centrilobular necrosis induced by the substance (HSDB (2003)). In addition, there is a report that exposure of rats to 0.02 - 0.25 mg/L for 4.5-month caused disorders of liver function and inhibition of nervous system (HSDB (2003)). Although these effects correspond to Category 1 based on guidance value range, the substance was classified into Category 2 (liver, nervous system) because of information in List 2 and non-meeting Decision criteria 1b 3).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 2	-	-	H401: Toxic to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Classified into Category 2 from its 24h-EC50 = 1.6 mg/L for Crustacea (Daphnia magna) (AQUIRE, 2010).
11	Hazardous to the aquatic environment （Long-term）	Category 2		-	H411: Toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1982).

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）