GHS Classification Result

Chemical Name：Hexanoic acid
CAS：142-62-1

Result：
ID: 21A3576
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Classification not possible - - - - Classification is not possible since no data are available under closed-cup test method. Flash point 102 degC (Chapman (Ver. 17.1, 2009), (Sax (11th, 2004)) is the data under open-cup.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 380 degC (Lide (88th, 2008), Sax (11th, 2004)) or 402 degC (Chapman (Ver. 17.1, 2009)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available. The substance is classified into Class 8, PG III in UNRTDG (UN2829).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on LD50 values of 6440 mg/kg bw, 3000 mg/kg bw (JECFA No.40 (1998)), and 5970 mg/kg bw (PATTY (5th, 2001)) for rats, the substance was classified as "Not classified".
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a LD50 value of 630 mg/kg bw for rabbits (PATTY (5th, 2001)), the substance was classified into Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on a LC50 value (2h) of 4.1 mg/L (4-hour equivalent: 2.05 mg/L) for mice (BUA 241 (2002)), the substance was classified into Category 4. Since the LC50 value was higher than saturated vapour pressure concentration (0.27208 mg/L), the test was considered to be conducted for mists.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on results that necrosis was followed by scar formation with the scars persisting for 21 days after application in a rabbit test (OECD TG404 (GLP)) (BUA 241 (2002)), the substance was classified into Category 1.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on a result of "severe burn for cornea" in a rabbit test (PATTY (5th, 2001), and classification as corrosive for the skin, the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Although there is a report that no positive reactions were observed in a maximization test on 26 volunteers (BUA Report 241 (2002)), classification was not possible due to lack of other test data.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of a negative Ames test (JECFA No.40 (1998), NTP DB (access on Aug. 2009, PATTY (5th, 2001)) and a negative (without metabolic activation) (false positive with metabolic activation) mouse lymphoma test (JECFA No.40 (1998)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available. As relevant information, there is a report of "irritating to the respiratory tract" as an effect of short-term exposure in ICSC (J) (1998).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - There are reports for two, 3-week feeding tests with rats (dose level: approximately 1000, 2000, and 4000 mg/kg (90-day equivalent: 233, 467 and 933 mg/kg)). One test reported no effects on liver peroxisome or peroxisome-related enzymes (JECFA No.40 (1998)). The second test noted a decreased serum triglyceride level but no decrease in cholesterol level in the low dose group and no effects on triglyceride or cholesterol level in the middle or high dose group (BUA Report 241 (2002)). There are no reports of effects on the other organs. Additionally, there is a report that there were no effects on the glandular stomach or forestomach in a 150-day feeding test with rats (dose level: about 5000 mg/kg) (JECFA No.40 (1998)). Based on all of these results, the substance corresponds to "Not classified" with oral exposure. However, classification was not possible due to lack of data with other exposure routes.
10 Aspiration hazard Classification not possible - - - - No data available. There is a report of "If this liquid is swallowed, aspiration into the lung may result in chemical pneumonitis" (ICSC (J) (1998)).

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 96h-LC50 = 88 mg/L for fish (Fathead minnow) (AQUIRE, 2010; HSDB, 2006; BUA 241, 2002).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 since its acute toxicity is Category 3 and there are no reliable data on rapid degradation.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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