GHS Classification Result

Chemical Name：2-Mercaptoethanol
CAS：60-24-2

Result：
ID: 21A3577
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified into Category 4 since flash point 74 degC (open-cup) (HSDB (2006)) is >60 degC and <=93 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 295 degC (IUCLID (2000)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a LD50 value of 244 mg/kg bw for rats (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (7th, 2009)), the substance was classified into Category 3.
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on LD50 values of 150 mg/kg bw (HSDB (2006)), 112 - 224 mg/kg bw (IUCLID (2000)) and 1600 mg/kg bw (IUCLID (2000)) for rabbits, the substance was classified into Category 2.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data. Although a LC50 value of 13,200 mg/m3 (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (7th, 2009)), the exposure period was not clear.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on results of "corrosive" in 20-hour application test with rabbits and "irritation" (application period was not clear) (IUCLID (2000)), and a report that skin contact causes redness and pain (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 7 (2009)), the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on a result that toxic effects on the conjunctiva were observed and long-lasting moderately severe corneal opacity were caused in a rabbit eye application test (HSDB (2006)), and a report that eye contact causes redness and pain (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 7 (2009)), the substance was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there is a report of a positive Chinese hamster V79 cells chromosomal aberration test (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In a test where rats were orally administered before mating and continuously through gestation and weaning of their pups at dose levels of 15, 50, 75 mg/kg/day, decreased viability index on postnatal day 4 in 50 mg/kg/day and higher groups, and increased postimplantation loss and a decreased number of pups born alive in the 75 mg/kg/day group were observed as toxic effects on fertility and development (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (vol. 7 2009)). However, these results were not used as the basis of classification since the females in these group showed high mortality during gestation and postnatal periods (3/10 females in the 50 mg/kg/day group, 4/10 females in the 75 mg/kg/day group). In a second test where rats were orally administered from day 12 to day 16 of gestation at a dose level of 67 mg/kg/day, slightly decreased maternal bodyweight gain, increased resorption ratio and slightly decreased number of pups born alive were reported (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (vol. 7, 2009)). The effects from the second test were not considered to be significant effects. In conclusion, classification was not possible.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system) Warning H371: May cause damage to organs (central nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there is report that the substance may cause effects on the central nervous system (HSDB (2006), ICSC (2001)) and the information is in a document in List 2 and List 3, the substance was classified into Category 2 (central nervous system).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In a rat 2-week oral test, death, enlargement of the liver, and increased serum transaminase were noted at the highest dose of 100 mg/kg/day (90-day equivalent: 15.4 mg/kg/day) (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 7 (2009)). In a rat 7-week oral test, pale liver, hepatocellular hypertrophy and vacuolization were noted at the 50 mg/kg/day (90-day equivalent: 27 mg/kg/day) and higher dose levels (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 7 (2009)). In a 28-time repeat oral administration test with guinea pigs (22.4 to 112 mg/kg/day), decreased liver function was observed (IUCLID (2000)). Since the effects on the liver are observed at dose levels within the guidance value range for Category 2, the substance was classified into Category 2 (liver).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 from its 48h-EC50 = 0.4 mg/L for Crustacea (Daphnia magna) (SIDS, 2005).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (SIDS, 2005).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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