GHS Classification Result

Chemical Name：Sulfamic acid
CAS：5329-14-6

Result：
ID: 21A3578
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Not combustible solid (Hommel (1996))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - The substance is not combustible solid (Hommel (1996)) and decomposes into sulfur trioxide, sulfur dioxide, water, ammonia and nitrogen at 209 degC (Ullmanns (E) (2003)).
11 Self-heating substances and mixtures Not classified - - - - Not combustible solid (Hommel (1996))
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - Classified into Not classified from "No oxidizing properties" (IUCLID (2000)).
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - LD50 values are >2000 mg/kg (OECD TG401 (GLP)), 3160 mg/kg, 2065 mg/kg, 1450 mg/kg and 1600 mg/kg (IUCLID (2000)) for rats. Since three values correspond to "Not classified" and two values correspond to Category 4, the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 in GHS classification) since 3 of 5 LD50 values are in this category.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on a result of "irritating" in rabbit test (OECD TG404 (GLP)) (IUCLID (2000)), and results of "not irritating" to "highly irritating" in other rabbit tests (IUCLID (2000)), and the EU classification as Xi; R36/38, the substance was classified into Category 2. As relevant information, a 1% solution of this substance has pH 1.18 (Merck (14th, 2006)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on a result of "irritating" in rabbit test (OECD TG405 (GLP)) (IUCLID (2000)), and results of "moderately irritating" to "highly irritating" in other rabbit test (IUCLID (2000)), and the classification as Xi; R36/38 in EU classification, the substance was classified into Category 2. As relevant information, there is a report that a 1% solution of this substance has pH 1.18 (Merck (14th, 2006)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - Based on a negative result in an oral mouse erythrocyte micronucleus test (OECD TG474 (GLP)) (in vivo somatic cell mutagenicity tests) (IUCLID (2000)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there is a report of a negative Ames test (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a 90-day rat feeding test (OECD TG408 (GLP)), delayed growth and weight increase in different relative organs were noted at 20,000 ppm and some animals displayed slight fattiness in kidney tubule (IUCLID (2000)). Based on a reported NOAEL of 10,000 ppm (correspond to 500 mg/kg bw/day), the substance corresponds to "Not classified" with oral exposure. However, classification was not possible due to lack of data with other exposure routes. As relevant information, there is a report that long-term exposure to the acid fumes of the substance often causes bronchial irritation and bronchopneumonia (DHP (13th, 2002)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 96h-LC50 = 70.3 mg/L for fish (Fathead minnow) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 since its acute toxicity is Category 3 and it is not rapidly degradable (BIOWIN).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information