NITE - Chemical Management Field

GHS Classification Result

Chemical Name：Decane
CAS：124-18-5

Result：


ID:	21A3579
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2009
Reference Manual:	GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3		Warning	H226: Flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Classified into Category 3 since flash point 46 degC (closed-cup) (NFPA (13th, 2006)) is >=23 degC and <=60 degC.
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	-	-	-	-	Auto-ignition point is 205 degC (Ullmanns (E) (2003)) exceeding 70 degC.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	Organic compounds containing no oxygen, fluorine or chlorine
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on a LD50 value of >5000 mg/kg for rats (OECD TG401) (IUCLID (2000)), the substance was classified as "Not classified".
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on a LD50 value of >2000 mg/kg for rats (IUCLID (2000)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Not classified	-	-	-	-	Based on a LC50 value of 72.3 mg/L/2h (51.1mg/L/4h) for mice (PATTY (5th, 2001)), the substance was classified as "Not classified". Since the LC50 value was higher than the saturated vapour pressure concentration (11.0 mg/L), the test was considered to be conducted for mists.
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on a result of "slightly irritating" in a rabbit test (OECD TG404 (GLP)) (IUCLID (2000)) and "slightly irritating" in another rabbit test (Directive 84/449/EEC, B.4) where the maximum mean score was 1.5 for erythema at 72-hour after application (IUCLID (2000)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 3 in GHS classification). As relevant information, there is a report of "no irritation " in tests with human subjects where a 30% solution was applied to skin for 24-hour (HSDB (2003)).
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	Based on results of "not irritating" in a rabbit test (OECD TG405 (GLP)) where maximum mean score was 1 for conjunctiva at 24 and 48-hour after application (IUCLID (2000)) and "not irritating" in another rabbit test (Directive 84/449/EEC, B.5) where maximum mean score was 1 for conjunctiva at 24-hour after application (IUCLID (2000)), the substance was classified as "Not classified".
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there is a report of a negative Ames test (NTP DB (access on June 2009)).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	There were no deaths at 5000 mg/kg in a oral acute toxicity test with rats (OECD TG401 (GLP)) (IUCLID (2000)). There were no deaths or abnormal gross pathological findings noted at 2000 mg/kg in a dermal acute toxicity test with rats (OECD TG402 (GLP)) (IUCLID (2000)). There were no deaths or specific clinical signs observed at 8 mg/L/8h (mist) in an inhalation acute toxicity test with rats (OECD TG403) (IUCLID (2000)). The dose levels exceeded the guidance value ranges and no significant toxic effects were produced by these 3 exposure routes at dose levels within the guidance value range. However, exposure of mice to 540 ppm (3.14 mg/L/3.75h) caused deaths but the cause of death was not reported (HSDB (2003)). Based on the results of the reported tests, the substance corresponds to "Not classified" for oral and dermal exposure, but classification was not possible comprehensively due to lack of sufficient data with vapour inhalation exposure.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	Although there are reports that vapour exposure to rats at 540 ppm (3.14 mg/L/18h) for 57 days decreased the total white blood count (PATTY (5th, 2001) and dermal application to mice (0.1 - 0.15 g per mouse, for 50 weeks) caused effects on the kidney and lung (PATTY (5th, 2001)), these findings are observed at high dose level exceeding the guidance value range. Therefore, classification was not possible due to lack of data.
10	Aspiration hazard	Classification not possible	-	-	-	-	Classification not possible due to lack of data. The substance has kinematic viscosities of 1148 mm2/s (25 degC) and 819 mm2/s (50 degC). Rats exposed to 0.2 mL of decane by inhalation died within 24-hour by pulmonary edema and hemorrahaging. Decane is highly lipid-soluble and causes pulmonary pneumonitis when aspirated (PATTY (5th, 2001)).

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1 from its 48h-EC50 = 0.029 mg/L for Crustacea (Daphnia magna) (IUCLID, 2000).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1 since its acute toxicity is Category 1 and the bioconcentration potential is estimated to be high from LogPow = 5.01 (PHYSPROP Database, 2010).

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）