GHS Classification Result

Chemical Name：Methyl chloroacetate
CAS：96-34-4

Result：
ID: 21A3580
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified into Category 3 since flash point 52 degC (closed-cup) (IUCLID (2000)) is >=23 degC and <=60 deg.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 465 degC (Hommel (1996)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on LD50 values of 107 mg/kg and 140 mg/kg for rats (DFGOT vol. 9 (1998)), the substance was classified into Category 3.
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		LD50 values of 137 mg/kg (DFGOT vol. 9 (1998)) and 470 mg/kg (DFGOT vol. 9 (1998)) for rats corresponds to Category 2 based on the lower value. A LD50 value of 318 mg/kg (DFGOT vol. 9 (1998)) for rabbits corresponds to Category 3. The rats data with higher hazard was adopted and the substance was classified into Category 2.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on LC50 values of approximately 300 ppm (DFGOT vol. 9 (1998)) and 210 - 315 ppm (OECD TG403 (GLP), IUCLID (2000)) for rats, the substance was classified into Category 2. Since the LC50 values were lower than 90% of saturated vapour pressure concentration (10,039 ppm), the classification criteria for gas was adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In rabbits, following occlusive application of 0.5 mL (approximately 300 mg/kg), the skin was greatly swollen and corroded and all animals died after 2 to 8-hour (DFGOT vol. 9 (1998)). Occlusive application of 125 mg/kg to the skin for 24-hour led to severe skin damage and corrosion (DFGOT vol. 9 (1998)). Additionally, in another rabbit test (FDA guideline), it was reported that severe to very severe erythema and oedema, as well as necrosis, and the primary irritation value was between 6.6 and 6.8 (BUA 150 (1994)). Based on these data, the substance was classified into Category 1 since the irreversible damages were observed in one and more test.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on a report that "severe irritation" and irreversible corneal damage (vascularization, detachment, scarring) and inflammation of the iris were observed after administration into the conjunctiva sac of the eye in a rabbit test (DFGOT vol. 9 (1998)) and results of severe mucous membrane irritant on the basis of the highest irritation index of 64 after 72-hour in another rabbit test (FDA guideline) (BUA 150 (1994)), the substance was classified into Category 1. As relevant information, in EU classification, the substance is classified into Xi; R41 (EU-Annex I (access on Aug. 2009)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on a result of positive (positive ratio: 65% (13/20) vs. control positive ratio: 0% (0/10)) in a guinea pig maximization test (DFGOT vol. 9 (1998)), the substance was classified into Category 1. As relevant information, there is a human case report that a 28-year-old man showed strong positive reaction in patch test after accidental exposure to this substance (DFGOT vol. 9 (1998)).
5 Germ cell mutagenicity Not classified - - - - Based on a negative result in an oral mouse bone marrow micronucleus test (in vivo somatic cell mutagenicity tests) DFGOT vol. 9 (1998)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there is a report of a negative Ames test (DFGOT vol. 9 (1998)).
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data. There is a report that there was no increased incidence of lung tumours in a test where mice received intraperitoneal injections for 8 weeks and follow-up for an additional 16 weeks (DFGOT vol. 9 (1998)).
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (systemic toxicity)
H335: May cause respiratory irritation (respiratory tract irritation) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		In rat oral acute toxicity tests, the animals showed clinical symptoms such as dyspnea, passivity, apathy, squatting position, abdominal position, disorders of balance, diarrhea, and ruffled fur. Autopsy of the animals which had died gave findings such as liver, spleen and kidneys coloured deep brown, dilatation of the heart, congestive hyperaemia, and bloody corrosive gastritis (BUA 150 (1994)). In rat inhalation acute toxicity tests, the animals showed intoxication symptoms such as impairment of the respiratory system and of coordinated movements and reflexes, an increased tendency to clean themselves, red incrusted noses and cyanosis, in addition to non-specific symptoms such as prone position and disorders of balance (DFGOT Vol. 9 (1998)). Autopsy of the animals which had died showed changes in the lungs and gastro-intestinal tract (BUA 150 (1994)). In dermal acute toxicity tests with rats and rabbits, the animals showed skin symptoms such as erythema and oedema, and autopsy of the animals which had died showed redness of the small intestine with injected blood vessels, as well as deep brown coloured livers (BUA 150 (1994)). Following oral and dermal application, autopsy of the surviving animals showed no abnormalities macroscopically, but following inhalation exposure, enlargement and coloured of the lungs was observed (BUA 150 (1994)). From the LD50 values (oral: 107 - 140 mg/kg, dermal: 136 - 318 mg/kg, inhalation: 0.945 - 1.418 mg/L), the toxic effects were observed at dose levels within the guidance value range for Category 1. However, the affected organ cannot be identified and the information are reported in a document in List 2, so the substance was classified into Category 2 (systemic toxicity). In addition, based on a report that concentrations of 210 ppm or more led to severe irritation of the respiratory tract (DFGOT vol. 9 (1998)), the substance was classified into Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a inhalation test with rats exposed to vapour for 28 days, squatting position, irregular breathing, uncoordinated gait, impaired body weight gain, and increased relative lung weight were observed at the highest dose level of 100 mL/m3 (0.45 mg/L, 90-day equivalent: 0.14 mg/L) (DFGOT vol. 9 (1998)). However, since these effects showed some level of reversibility and no effects were noted in gross or histopathological examination (BUA 150 (1994)), the effects are not considered to be significant toxic effects. Since the dose levels were at the low end of the guidance value range, classification was not possible due to lack of other sufficient data.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 2 from its 96h-LC50 = 1.13 mg/L for fish (Zebrafish) (IUCLID, 2000; BUA 150, 1994).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (BOD degradation rate = 32, 29, 75% at 4 weeks) (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1989).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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