GHS Classification Result

Chemical Name：1,4-Naphthoquinone
CAS：130-15-4

Result：
ID: 21A3582
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on LD50 values of 190 mg/kg bw and >300 mg/kg bw for rats (BUA 211 (1998)), the lower value (190 mg/kg bw) was adopted and the substance was classified into Category 3.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a LC50 value of 0.046 mg/L/4h for rats (BUA 211 (1998)), the substance was classified into Category 1. Since the LC50 value was higher than saturated vapour pressure concentration (0.001439 mg/L), the test was considered to be conducted for dust.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on results of "highly irritating" or "severe irritation" in rabbit tests (BUA 211 (1998)), reports of skin irritating in occupationally exposed workers (BUA 211 (1998)), and a report that human skin contact with the wet powder may cause highly irritating or corrosion and subsequently the injury may gradually resolve without complication (BUA 211 (1998)), the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on results of "highly irritating" or "severe irritation" in rabbit tests (BUA 211 (1998)) and reports that "severe irritating" to the eye were observed after exposure in human (BUA 211 (1998)), the substance was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - Although there are results showing positive reactions in a guinea pig respiratory sensitization tests (BUA Report No. 211 (1998)), it is reported that evaluation of the respiratory sensitization was impossible since the data processing and reporting were not adequate and observed reactions may be attributed to irritation (BUA Report No. 211 (1998)). Classification was not possible due to lack of sufficient data.
4 Skin sensitization Classification not possible - - - - Although sensitizing results in a guinea pig skin sensitization test are reported (BUA 211 (1998)), classification was not possible since the information is reported in a document in List 2 and the test method is not approved by OECD.
5 Germ cell mutagenicity Not classified - - - - Based on a negative result in an oral Chinese hamster bone marrow chromosome aberration test (in vivo somatic cell mutagenicity tests) (BUA 211 (1998)), the substance was classified as "Not classified". From in vitro mutagenicity tests, there are reports of negative Ames tests and gene mutation test (HGPRT assay) (BUA 211 (1998)) but a positive chromosomal aberration test (BUA 211 (1998)). As relevant information, the substance is an existing chemical substance, for which mutagenicity was established (Kiankahatsu No. 0827010, August 27, 2004) under the provisions of Article 57-3 of the Industrial Safety and Health Law.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - Although there is a reported that no effect on pregnancy was noted in an oral administration test with mice during gestation days 6 - 12 (BUA 211 (1998)), the test was conducted in an earlier time (in 1958), the dosage levels were not clear and no data for fertility were indicated. Therefore, classification was not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 2 (blood system, liver), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (blood system, liver)
H335: May cause respiratory irritation (respiratory tract irritation) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on a result that oral 500 mg/kg exposure of rats resulted in the formation of methemoglobin followed by the appearance of Heinz bodies and development of hemolytic anemia, the substance was classified into Category 2 (blood system). Additionally, since hepatocellular vacuolization and necrosis in a rat inhalation test (0.021 - 0.065 mg/L) and centrilobular hemorrhagic necrosis in a rat oral test (100 - 300 mg/kg) were reported as histopathological findings in dead animals (BUA 211 (1998)), the substance was classified into Category 2 (liver). Although some of these results correspond to Category 1 based on guidance value range, it was classified into Category 2 because of information in List 2. Additionally, respiratory tract irritation for human was reported and it was concluded that the substance caused severe irritation to the upper respiratory tract. Irritating lesions in the lung were observed in a mouse inhalation test based on decreased respiratory rate without histopathological change (BUA 211 (1998)), Based on all information, the compound was classified into Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 2 (blood system, liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		A decreased number of erythrocytes in the blood, depressed phagocytic activity of leukocytes and decreased hemoglobin levels in the blood as well as appearance of methemoglobin and Heinz bodies in the blood were reported as human effect (HSDB (2006)). In a rat 6-month inhalation (dust) test (4-hour/day), the findings of hepatic dysfunction such as positive thymol test, decreased glycogen level and degeneration of hepatic parenchyma cell were observed at concentrations of 0.7 mg/m3/4 hr (0.0005 mg/L/6 hr) and higher (BUA 211 (1998)). Additionally, hepatotoxicity is reported as human toxicity excerpts (HSDB (2006)). Since the blood system and liver are regarded as target organs and these information are reported in a document in List 2, the substance was classified into Category 2 (blood system, liver). Although changes in hematological parameters including formation of methemoglobin and central nervous system disorder were observed in a rat 30-day oral test (BUA 211 (1998)), this information is not used as the basis of classification since data for the protocol and results are insufficient and there is a comment that this test is inadequate to evaluate systemic effects (BUA 211 (1998)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Classification not possible due to lack of data.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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