GHS Classification Result

Chemical Name:Strontium nitrate
CAS:10042-76-9

Result:
ID: 21A3587
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - The substance is classified into Division 5.1 (Oxidizing substances), PG III in UNRTDG (UN1507) though it contains chemical groups (nitrates) associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Not combustible (Hommel (1996))
8 Self-reactive substances and mixtures Not applicable - - - - The substance is classified into Division 5.1 (Oxidizing substances), PG III in UNRTDG (UN1507) though there are chemical groups (nitrates) associated with explosive properties present in the molecules.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Not combustible (Hommel (1996))
11 Self-heating substances and mixtures Not classified - - - - Not combustible (Hommel (1996))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - The substance is estimated to be stable against water since data is available that water solubility is 70.9 g/100 mL water at 18 degC, 100 g/100 mL water at 100 degC (HSDB (2003)).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Category 3 Warning H272: May intensity fire; oxidizer P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P221: Take any precaution to avoid mixing with combustibles/...
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
The substance is classified into Division 5.1, PG III in UNRTDG (UN1507).
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on a LD50 value of 5675 mg/kg (2350 mg strontium/kg) for mice (ATSDR (2004)), the substance was classified into "Not classified".
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on reports of "marked skin irritation" in rat and guinea pig tests (DFGOT vol. 25 (2009)) and "irritated the skin" in rabbits by topical application (HSDB (2003)), the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on reports of "weakly irritated the conjunctival membrane in rabbits" (HSDB (2003)) and "highly irritating to the skin but only slightly irritating to the mucosa" (HSDB (2003)), the substance was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - Although there is a report that no effect for fetal development was noted in a subcutaneous injection test with rats during gestation days 9 - 19 (DFGOT vol. 25 (2009)), this test is insufficient due to small number of animals (3/group) and no data for the effects on sexual function and fertility. Therefore, classification was not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Classification not possible due to lack of data. As relevant information, as only information on the adverse effects, there is a case report of a 35-year-old female paramedic who developed a sudden, severe reaction upon inhaling fumes from a flare that contained strontium as strontium nitrate (ATSDR (2004)). Initial symptoms included coughing, wheezing, and shortness of breath, and recovery ultimately required sedation, intubation, and intensive care for several days. Her medical history included several significant contributing factors which may have resulted in her severe reaction. Additionally, inhalation of flare combustion products are known to be irritating to the respiratory tract. Therefore, the exact contribution of strontium in this case is uncertain (ATSDR (2004)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to lack of data. As relevant information, there is an report that when rats were exposed to 44.6 mg/m3/4 hr for a month, decreased leukocyte count, changes in urine volume and component, increased synthesis function of the liver, histological findings such as interstitial pneumonia in the lungs, atrophy of the lymphatic system, dystrophy of hepatocytes and dystrophy in the epithelium of the renal tubules were seen (DFGOT vol. 25 (2009)). Since no details of test animals and compound were given and no report of method is provided, this test cannot be considered valid. Nevertheless, it gives an indication of systemic effects after inhalation of strontium compounds (DFGOT vol. 25 (2009)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Classification not possible due to lack of data.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - Classification not possible due to lack of data.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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