GHS Classification Result

Chemical Name：2-Octanone
CAS：111-13-7

Result：
ID: 21A3593
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified into Category 3 since flash point 52 degC (closed-cup) (HSDB (2006)) is >=23 degC and <=60 degC. Data are available that flash point is 71 degC (closed-cup) (Solvents Handbook, Ohmsha Ltd. (1994)). It is >60 degC and <=93 degC, and falls into Category 4. However, the classification was classified into Category 3 by adopting lower flash point.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 295 degC (GESTIS (access on 8, 2009)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - LD50 values are 3.2 g/kg, >5 g/kg and 9.2 g/kg for rats (PATTY (5th, 2001)). Since one value corresponds to Category 5 and two values correspond to "Not classified", the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification).
1 Acute toxicity （Dermal） Not classified - - - - Based on a LD50 value of >5 g/kg for rabbits (PATTY (5th, 2001)), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data. As relevant information, a LC50 value was >2132 ppm/6h (16.77 mg/L/4h) for rats (RTECS (2006)). Since the LC50 value (2132 ppm) was higher than saturated vapour pressure concentration (1776 ppm), the test was considered to be conducted for mists.
2 Skin corrosion/irritation Not classified - - - - Based on results of "slight irritation" in a rabbit test where 500 mg was applied to the skin for 24-hour (PATTY (5th, 2001)) and "not irritation" in 48-hour patch test with human subjects (PATTY (5th, 2001)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 3 in GHS classification).
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on a result of "slight irritation" in a rabbit test where undiluted substance was applied to the eye (PATTY (5th, 2001)), the substance was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Although there are results that no skin sensitization reactions were noted in patch test on 25 human subjects (PATTY (5th, 2001)) and that no skin sensitizing was induced in modified Draize test using animals (PATTY (5th, 2001)), classification was not possible since the detailed data such as test methods and results are not clear.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there is a report of a negative Ames test (PATTY (5th, 2001)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		When guinea pigs were exposed to saturated atmospheres, exposure for 10-hour produced evidence of central nervous system depression, and after 12-hour of exposure, the animals were comatose (PATTY (5th, 2001)). In addition, based on a report for human effects that inhalation may cause CNS depression at high concentrations (HSDB (2006)), the substance was classified into Category 3 (narcotic effects). On the other hand, based on reports that guinea pigs exposed to saturated atmospheres developed immediate signs of nasal irritation and that respiratory depression was reported in mice a inhalation test, and that inhalation may produce mild symptoms of throat irritation at low concentrations as human information (PATTY (5th, 2001)), the substance was classified into Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available. As relevant information, there is information that 4 of 5 rats died within minutes after dosing into the trachea. Increased lung weights and pulmonary hemorrhages were observed in dying rats (HSDB (2006)).

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 96h-LC50 = 36 mg/L for fish (Fathead minnow) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 since its acute toxicity is Category 3 and there are no data on rapid degradation.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information