GHS Classification Result

Chemical Name:Cyclohexyl acetate
CAS:622-45-7

Result:
ID: 21A3597
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Classified into Category 3 since flash point 58 degC (closed-cup) (ICSC (1996)) is >=23 degC and <=60 degC. The substance is classified into Class 3, PG III in UNRTDG (UN2243).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 330 degC (Chapman (Ver. 17.1, 2009)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on a LD50 value of 6.73 g/kg for rats (PATTY (5th, 2001)), the substance was classified into "Not classified".
1 Acute toxicity (Dermal) Not classified - - - - Based on a LD50 value of 10.1 g/kg for rabbits (PATTY (5th, 2001)), the substance was classified as "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data. As relevant information, there are LC50 values of 9 mg/L/10.5h for cats (15 mg/L/4h; 2580 ppm/4h) and LC50 of 9 mg/L/4.8h for rabbits (10 mg/L/4h; 1720 ppm/4h) (PATTY (5th, 2001)). These values correspond to Category 2 and 3, respectively. Since saturated vapour pressure concentration is 14473 ppm (84.2 mg/L), the test was considered to be conducted for vapour with almost no included mists.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - Classification not possible due to lack of data. As relevant information, there is a report of "moderate irritating" in a rabbit standard Draize test where 100 or 500 mg was applied to the skin for 24-hour (RTECS (1997)) and a report that the substance is irritating to the skin, eyes and respiratory tract (ICSC (2005)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on reports of eye irritating in rabbit and human inhalation tests (PATTY (5th, 2001)), the substance was classified into Category 2B. As relevant information, there is a report of "mild irritating" at 24-hour after instillation of 500 mg to the eye in a rabbit standard Draize test (RTECS (1997)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (systemic toxicity)
H335: May cause respiratory irritation (respiratory tract irritation)
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
There is a report that inhalation exposure to rabbits caused irritation to nose and eyes but with complete recovery (PATTY (5th, 2001)). Additionally, it is reported that inhalation exposure caused irritation to nose and eyes in cats and human (PATTY (5th, 2001)). Based on this information, the substance was classified into Category 3 (respiratory tract irritation). Inhalation tests resulted in a LC50 value of 9 mg/L/10.5h (15 mg/L/4h) for cats and a LC50 value of 9 mg/L/4.8h (10 mg/L/4h) for rabbits. Deaths were observed at dose levels within the guidance value range for Category 2 (PATTY (5th, 2001)), however, the affected organ was not identified, so the substance was classified into Category 2 (systemic toxicity).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to lack of data. Although there is a report of "no symptoms" when cats were exposed via inhalation at a concentration of 637 ppm for 30 days (8 hr/day) (PATTY (5th, 2001)), classification was not possible since details are unclear.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Classified into Not classified from its 24h-EC50 = 164 mg/L for Crustacea (Daphnia magna) (AQUIRE, 2010).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Classified into Not classified since its acute toxicity is Not classified and it is not non-water soluble from water solubility = 728 mg/L (PHYSPROP Database, 2010).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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