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GHS Classification Result

Chemical Name：Sodium hydrogen difluoride
CAS：1333-83-1

Result：


ID:	21A3602
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2009
Reference Manual:	GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Not classified	-	-	-	-	Not combustible (Hommel (1996))
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	-	-	-	-	Not combustible (Hommel (1996))
11	Self-heating substances and mixtures	Not classified	-	-	-	-	Not combustible (Hommel (1996))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	The substance is considered to be stable against water since data is available that water solubility is 2.25 g/100 g H2O (Lide (88th, 2008)). Data is available that it gradually reacts in water and becomes corrosive solution in water, but this reaction is not dangerous (Weiss (2nd, 1986)).
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	-	-	-	-	No data available.
15	Organic peroxides	Not applicable	-	-	-	-	Inorganic compound
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available. The substance is classified into Class 8, PG II in UNRTDG (UN2439). Information is available that is "The substance is not corrosive to most ordinary packing materials in the solid or dry state. Solution in water having strong corrosive properties is formed in presence of moisture, water vapor or water and is highly corrosive to many metals." (Hommel (1996)).

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Classification not possible	-	-	-	-	No data available. For health hazards, refer also to sodium fluoride (CAS 7681-49-4).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available. As relevant information, in EU classification, the substance is classified into C; R34 (EU-Annex I (2009)).
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	No data available. As data of sodium fluoride (CAS 7681-49-4), there are reports of positive results in a mouse bone marrow in vivo micronucleus test and a chromosomal aberration test when administered by intraperitoneal injection, but negative results was reported when administered orally (ATSDR (2003)). In the human hazard assessment, "Not classified" is considered to be appropriate.
6	Carcinogenicity	Not classified	-	-	-	-	Inorganic fluorides are classified into "Group 3" in IARC (IARC suppl. 7 (1987)).
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system)		Danger	H370: Causes damage to organs (respiratory system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Although no data for the substance is available, the substance was classified into Category 1 (respiratory system) based on a report that death is usually caused by respiratory paralysis in human cases of fluoride poisoning (IARC vol. 27 (1982)). As relevant information, there is a report that lethal doses of inorganic fluoride compounds were 50 - 225 mg/kg, and acute congestion of the abdominal organs, edema of the liver, kidney and renal tube, hemorrhage of the lung and dilatation of the right ventricle were observed at necropsy (IARC vol. 27 (1982)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (tooth, bone, kidney)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (tooth, bone, kidney)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	No data for the substance is available. However, in human cases, chronic exposure of fluoride compounds can impair the teeth, bone and kidney, and continuous ingestion of inorganic fluoride compounds can promote osteosclerosis by accumulation of fluorides in the bone. In areas with drinking water containing 5 - 16.2 ppm fluoride, low urea clearance and glomerular filtration rate, high blood urea level, as well as increases in incidence of skeletal deformity and renal calculus were reported. Additionally, dental fluorosis can occur when daily mean fluoride concentration in the drinking water and food is 2 ppm and above (IARC vol. 27 (1982)). Based on these information, the substance was classified into Category (tooth, bone, kidney).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Classification not possible	-	-	-	-	No data available.
11	Hazardous to the aquatic environment （Long-term）	Classification not possible	-	-	-	-	No data available.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）