GHS Classification Result

Chemical Name:1,5,9-Cyclododecatriene
CAS:4904-61-4

Result:
ID: 21A3605
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Classified into Category 4 since flash point 93 degC (closed-cup) (Hommel (1996)) is >60 degC and <=93 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Type G - - - - Classified into Type G since the substance is considered not to fall into upper class of Self-reactive substances and mixtures from which it is classified into Division 6.1, PG II in UNRTDG (UN2598) though there are chemical groups (unsaturated bond) present in the molecule associated with self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 244 degC (Hommel (1996)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on a LD50 value of 4150 - 4664 mg/kg bw for rats (OECD TG401 (GLP)) (IUCLID (2000)), the substance was classified into "Not classified" in JIS Classification (correspond to Category 5 in GHS classification).
1 Acute toxicity (Dermal) Not classified - - - - Based on a LD50 value of >3600 mg/kg bw for rats (IUCLID (2000)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - Based on a LC50 value of 7.5 - 8.9 mg/L/6h (4-hour equivalence: 11.25 - 13.35 mg/L/4h) for rats (IUCLID (2000)), the substance was classified as "Not classified". Since the LC50 value (7.5 - 8.9 mg/L) was higher than saturated vapour pressure concentration (0.728 mg/L), the classification criteria for mist was adopted.
2 Skin corrosion/irritation Not classified - - - - The result of "not irritating" was reported in a rabbit test (OECD TG404) where redness and edema scores were 1.00 and 0.61, respectively and irritation index was 1.25/8 (IUCLID (2000)). Additionally, in a second rabbit test (GLP), a result of "not irritating" was reported where redness and edema scores were 1.35 and 0.79, respectively (IUCLID (2000)). Based on these results, the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - Based on a result of "not irritating" in a rabbit test (OECD TG405) where corneal opacity, iritis, conjunctivae redness and chemosis scores were 0.17, 0, 0.50 and 0.22, respectively, and irritation index was 3/110 (IUCLID (2000)), the substance was classified as "Not classified".
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - There is a result of not sensitizing (positive ratio: 5 - 10%, 1/20 - 2/20 animals) in a guinea pig maximization test (IUCLID (2000)) and a result of not sensitizing (positive ratio: 0%, 0/20 animals) was reported in another guinea pig maximization test (GLP) (IUCLID (2000)). Based on the negative results in two guinea pig maximization tests, the substance was classified as "Not classified".
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there is a report of a negative bacteria reverse mutation test using S. typhimurium and E. coli (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In a rat acute oral toxicity test (OECD TG401), 30 minutes after application animals showed abnormal symptoms (restlessness, decrease of responsiveness, tremors, convulsions, etc.) and animals which died during the test showed redness of the mucosa of the gut and stomach at necropsy (IUCLID (2000)). In a rat acute inhalation toxicity test, gasping, twitching and severe muscle spasms were observed (IUCLID (2000)). An oral LC50 value of 4150 - 4664 mg/kg was determined and a inhalation LC50 value of 11.25 - 13.35 mg/L/4h was determined. Since findings for both tests were observed at dose levels exceeding the upper limits of their guidance value ranges for Category 2, classification was not possible since effects at dosing levels within the guidance value range were not clear.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - 48h-EC50 is 5 mg/L for Crustacea (Daphnia magna) (IUCLID, 2000), however water solubility is 0.39 mg/L (PHYSPROP Database, 2009) and it is unable to specify the dosage which shows the toxicity. Therefore, it is classified into Classification not possible because of lack of data.
11 Hazardous to the aquatic environment (Long-term) Category 4 - - H413: May cause long lasting harmful effects to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 4 since it is non-water soluble (water solubility = 0.39 mg/L (PHYSPROP Database, 2009)), not rapidly degradable (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2003) and shows a bioconcentration potential (the highest value of BCF for 10 weeks: 14,800 in bioconcentration test with carp) (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2003)) without acute toxicity value at or lower concentration than water solubility.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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