GHS Classification Result

Chemical Name:Allyl acetate
CAS:591-87-7

Result:
ID: 21A3612
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Flash point is 6 degC (Hommel (1996)) is less than 23 degC and boiling point is 103.5 degC (Howard (1997)) exceeding 35 degC. The substance is classified into Class 3, Subsidiary risk 6.1, PG II in UNRTDG (UN2333).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Type G - - - - Classified into Type G since the substance is considered not to fall into upper class "Self-reactive substances and mixtures" from which it is classified into Class 3, Subsidiary risk 6.1, PG III in UNRTDG (UN2333) though there are chemical groups (unsaturated bond) present in the molecule associated with self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 374 degC (Hommel (1996)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on a LD50 value of 130 mg/kg for rats (PATTY (5th, 2001)), the substance was classified into Category 3.
1 Acute toxicity (Dermal) Classification not possible - - - - Classification not possible due to lack of data. As relevant information, a LD50 value is 1021 mg/kg for rabbits (RTECS (2006)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on a LC50 value of 1000 ppm/1h (500 ppm/4h) for rats (PATTY (5th, 2001)), the substance was classified into Category 2. Since the LC50 value (1000 ppm) was lower than 90% of saturated vapour pressure concentration (31579 ppm), the classification criteria for gas was adopted.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on reports that the substance causes "slight skin irritation" in a rabbit test (HSDB (2003)) and that the substance is skin irritant and contact with the undiluted substance can cause first- to second-degree burns (NTP TR48 (2006)), the substance was classified into Category 2
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Based on reports that the substance causes "moderate eye effect" in a rabbit test (HSDB (2003)) and that the vapour is irritating to mucous membranes and causes lacrimation and corneal burns (NTP TR48 (2006)), the substance was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - Although negative result for males and weakly positive result for females (negative for PCE, weakly positive for NCE) were obtained in a mouse peripheral blood micronucleus test (in vivo somatic cell mutagenicity tests) by oral administration for 13 weeks (up to 62.5 mg/kg), the dose dependency was not clear (NTP DB (access on June 2009)). On the other hand, in a rat bone marrow micronucleus test by oral administration 3 times at 24-hour intervals (up to 400 mg/kg), a negative result was obtained at 150 mg/kg where 2/5 rats died (NTP DB (access on June 2009)). Therefore, the substance was classified as "Not classified" with consideration for the weight of evidence. As relevant information, from in vitro mutagenicity tests, there are reports of positive (without metabolic activation) and negative (with metabolic activation) results in Ames test (NTP DB (access on June 2009)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (bone marrow, lymphatic system) Warning H373: May cause damage to organs through prolonged or repeated exposure (bone marrow, lymphatic system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In a rat and mouse oral (gavage) 14-week test, forestomach squamous epithelial hyperplasia was observed at dose levels within Category 2 (male rats: >12 mg/kg, female rats: 25 and 50 mg/kg, male mice: 32 and 62.5 mg/kg, female mice: 16, 32 and 62.5 mg/kg) and forestomach necrosis and hemorrhage were present in most rats (100 mg/kg). Male mice had significantly increased incidences of glandular stomach hemorrhage (62.5 mg/kg). Bone marrow hyperplasia, depletion in the lymph nodes and necrosis of the thymus were observed (rats: 100 mg/kg, mice: 62.5 mg/kg). Based on this information (NTP TR48 (2006)), the substance was classified into Category 2 (bone marrow, lymph system). Although adverse effects on the stomach are apparent, they are considered to be effects by site of contact due to oral (gavage) administration of an irritant and are not classified in specific target organ toxicity.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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