GHS Classification Result

Chemical Name：O,O-Dimethylchlorothiophosphonate
CAS：2524-03-0

Result：
ID: 21A3617
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point is >105 degC (Lange (16th, 2005)) is >93 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - The substance is estimated not to fall into upper Division 4.2 (Substances liable to spontaneous combustion), PG I since it is classified into Class 6.1, PG II in UNRTDG (UN2267).
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Classified into Not classified since the substance is not combustible gas though information is available that it gradually reacts with water forming hydrogen chloride having corrosive properties (IMDG (2006)).
13 Oxidizing liquids Classification not possible - - - - Classification is not possible since no data are available though the substance contains oxygen and chlorine which are chemically bonded to atoms except carbon.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		LD50 values of 664 mg/kg, 1260 mg/kg, 500 - 100 mg/kg, 1605 mg/kg, 360 mg/kg and 500 - 2000 mg/kg for rats (IUCLID (2000)) correspond to Category 4.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		A LD50 value of 590 mg/kg for rats (IUCLID (2000)) corresponds to Category 3 and LD50 values >2150 mg/kg, >1500 mg/kg and >1000 mg/kg for rabbits (IUCLID (2000)) correspond to Category 4 or "Not classified". The category for rats with higher hazard was adopted and the substance was classified into Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		LC50 values (4-hour) of 0.34 mg/L (51.8 ppm) and 0.48 mg/L (73.1 mg/L) for rats (IUCLID (2000)) correspond to Category 1. Since the LC50 values were lower than 90% of saturated vapour pressure concentration (4.32 mg/L), the classification criteria for gas was adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Since "highly irritating" after 4-hour application and "corrosive" after 24-hour application were reported in a rabbit Draize test (IUCLID (2000)), the substance was classified into Category 2 based on the result after a 4-hour application.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on results of "corrosive" or "highly irritating" in rabbit tests (IUCLID (2000)) and a report of "strong irritant to eyes" as human health effects (HSDB (2003)), the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Although there is a positive result in a rat dominant lethal test (in vivo heritable germ cell mutagenicity tests) using the formulation (HSDB (2003)), evaluation of this substance itself is difficult and a negative result was reported in a mouse micronucleus test (in vivo somatic cell mutagenicity tests) (HSDB (2003)). Therefore, classification was not possible. As relevant information, from in vitro mutagenicity tests, there are reports of a negative result in an Ames test and positive results in chromosomal aberration test using Chinese hamster ovary cells, gene mutation test using mouse lymphoma cells and morphological transformation test using mouse BALB/3T3 cells (HSDB (2003)). In addition, the substance is an existing chemical substance, for which mutagenicity was established under the provisions of Article 57-3 of the Industrial Safety and Health Law.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - Although there is a report that slightly increased preimplantation losses or early resorptions were observed at maternal toxicity doses in a rat developmental toxicity test by inhalation during organogenesis period (IUCLID (2000)), no changes in the same reproductive parameters were noted at higher doses in a previous dose finding test (IUCLID (2000)). Since the statistical significance of the slight increases was not indicated, classification was not possible.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In mice treated by ip injection, abnormal gait and hypersensitivity were observed at 200 mg/kg and ataxia, tremors, cyanosis, paralysis and ptosis were observed at 300 mg/kg (HSDB (2003)). In a rabbit dermal test, depressed activity was noted at 316 mg/kg within the guidance value range for Category 1 (RETCS (2006)). Additionally, the acute effects include miosis, blurred vision, headache, dizziness, muscle twitching, marked muscle weakness and vomiting, diarrhea, abdominal pain, convulsion and coma. Oral and dermal exposure can cause decreased heart rate (SITTIG (5th, 2008)). Additionally, exposure can cause severe organophosphate poisoning with headache, dizziness, blurred vision, tightness in the chest, sweating, nausea and vomiting, diarrhea, muscle twitching, convulsions and coma (HSFS (2001)). Since these information are obtained from ip injection test or documents in List 3, classification would be not possible according to the guidance. However, the substance is an organophosphate and signs associated with effects on nervous system were reported in documents in List 3, therefore, the substance was classified into Category 2 (nervous system).
9 Specific target organ toxicity - Repeated exposure Category 2 (respiratory system) Warning H373: May cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		There is a report that a respiratory distress syndrome and increased lung and trachea weights were observed at 0.030 mg/L in a rat 13-week inhalation test (GLP) (IUCLID (2000)). Although the substance correspond to Category 1 based on guidance value range, the substance was classified into Category 2 (respiratory system) because of information in List 2 and non-meeting Decision criteria 1b 3).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Classification not possible due to lack of data.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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