GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：1,2-Diethylbenzene
CAS：135-01-3
Result：
| ID: | 21A3625 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 3 |
|
Warning | H226: Flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Classified into Category 3 since flash point 57 degC (closed-cup) (HSDB (2003)) is >=23 degC and <=60 degC. The substance is classified into Class 3, PG III in UNRTDG (UN2049). |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Auto-ignition point is 395 degC (Lide (88th, 2008)) exceeding 70 degC. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine or chlorine |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | Classification not possible due to lack of data. As relevant information, all 10 animals died at 5000 mg/kg (PATTY (5th, 2001)). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. For health hazards, refer also to 1,4-diethylbenzene (CAS 105-05-5). |
| 3 | Serious eye damage/eye irritation | Category 2 |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Diethylbenzene tested by drop on a rabbit eye caused transient symptoms of irritation, but no injury was detected by fluorescein staining (HSDB (2003)). Additionally, it was reported that men exposed to 1000 ppm experienced eye irritation which rapidly diminished in intensity on continued exposure and a concentration of 2000 ppm caused immediately severe eye irritation, lacrimation (HSDB (2003)), and there is a report that diethylbenzene is an eye irritant (HSDB (2003)). Based on these information, the substance was classified into Category 2. [Data for diethylbenzene was used as the basis of classification on the assumption that there are only minor differences between isomers.] |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available. For health hazards, refer also to the information of 1,4-diethylbenzene (CAS 105-05-5). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. Refer also to the information of 1,4-diethylbenzene (CAS 105-05-5). |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | Although there is a report that slight hemorrhage and dystrophic change were observed in the liver, gastric mucosa, duodenum, spleen and kidney following oral application of isomer mixture to rats (PATTY (5th, 2001)), classification was not possible due to lack of data for the substance itself rather than isomer mixture. For health hazards, refer also to the information of 1,4-diethylbenzene (CAS 105-05-5). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (central nervous system) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (central nervous system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
The effects of 1,2-diethylbenzene on brainstem auditory evoked potentials (BAEPs) were studied in rats administered 75 or 100 mg/kg/day orally for 8 weeks (90-day equivalence: approximately 40 - 60 mg/kg/day) (HSDB (2003)). The administration was associated with severe hindlimb weakness and gait disturbances and increases in peak latencies, decreases in amplitude of all five components of the BAEP and prolonged interpeak latencies. Therefore, it was concluded that the substance is toxic to the central nervous system and the observed effects on the BAEP indicate that the substance induces functional alterations in the auditory pathways (HSDB (2003)). Since this result was observed at dosing levels within the guidance value range for Category 2 with oral route, the substance was classified into Category 2 (central nervous system). As relevant information, refer also to the information of 1,4-diethylbenzene (CAS 105-05-5). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | Although the substance is a hydrocarbon, classification was not possible since the kinematic viscosity at 40 degC was unknown. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | Classification not possible due to lack of data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | Classification not possible due to lack of data. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |