GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Difluoromethane
CAS：75-10-5
Result：
| ID: | 21A3655 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Flammable gases （including chemically unstable gases） | Category 1 |
|
Danger | H220: Extremely flammable gas |
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely. P381: Eliminate all ignition sources if safe to do so. P403: Store in a well-ventilated place. |
The substance is classified into Division 2.1 in UNRTDG (UN3252), and data are available that explosive limit is 27.2 vol% (Upper explosion limit in air). |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not classified | - | - | - | - | Flammable gas |
| 5 | Gases under pressure | Low pressure liquefied gas |
|
Warning | H280: Contains gas under pressure; may explode if heated | P410+P403: Protect from sunlight. Store in a well-ventilated place. | Critical temperature is 78.4 degC (Merck (14th, 2006)) exceeding 65 degC. |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Gas (GHS definition) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Gas (GHS definition) |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to gaseous substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | Classification not possible due to lack of data. As relevant information, a LD50 value is 1890 mg/kg for rats (RTECS (2007)). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not classified | - | - | - | - | Based on no mortality in male or female rats exposed at <=56000 ppm/4h (PATTY (5th, 2001), ECETOC (2008)), the substance was classified as "Not classified". |
| 1 | Acute toxicity （Inhalation: Vapours） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on a negative result in an inhalation mouse bone marrow micronucleus test (in vivo somatic cell mutagenicity tests) (PATTY (5th, 2001)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of negative Ames tests and chromosomal aberration tests using Chinese hamster lung cells or human lymphocytes (PATTY (5th, 2001)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | In developmental toxicity tests by inhalation exposure to rats and rabbits during organogenesis period, a slight reduction in food consumption or reduction of maternal bodyweight gain suggested a minimal effect on the dams. There was no adverse effect on number, growth and survival of fetuses. There was no increase in incidence of major defects except for slightly increased incidence of minor variants/defects compared to control animals in the rat test. Overall, the substance was not teratogenic in both species and showed minimal effect on fetal development (ECETOC JACC No. 32 (1995)). However, classification was not possible since there are no data for effect on sexual function and fertility by exposure before mating. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Narcotic effects） |
|
Warning | H336: May cause drowsiness or dizziness (narcotic effects) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on reports that a decrease in response to sound was observed in rats after inhalation of 82,000 ppm and higher concentrations which quickly resolved after cessation of inhalation (PATTY (5th, 2001)) and that preanesthesia signs (head and limb tremors, unsteady gait) were noted in a heart effect test, the substance was classified into Category 3 (narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | It was reported that no exposure related effects were observed in rat 4-week and 90-day inhalation tests. The NOEL was 50,000 ppm (90-day equivalence for 4-week test: 15,400 ppm) in both tests (PATTY (5th, 2001)). Since the NOEL exceeds the upper limit of the guidance value range (250 ppm), the substance corresponds to "Not classified" with inhalation exposure. However, classification was not possible due to lack of data with other exposure routes (oral, dermal). |
| 10 | Aspiration hazard | Not applicable | - | - | - | - | Gas (GHS definition) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | - | It is gaseous material at room temperature with boiling point = -51.6 degC (PHYSPROP Database, 2009) and reliable test data are not available. As the data used QSAR, SIDS reported 96h-LC50 = 629.2 - 1405 mg/L for fishes (fresh water), 48h-EC50 = 616.4 - 1573 mg/L for Crustacea (daphnid) and 72h-EC50 = 357.9 - 1888 mg/L for algae (green alga) (SIDS, 2004). It was classified into Not classified since its test is hard to be conducted and SIDS judged the results by QSAR to be reliable. |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Classified into Not classified since its acute toxicity is Not classified and all chronic toxicity values by QSAR for fishes, Crustacea and algae, which are judged to be reliable in SIDS, are more than 1 mg/L (SIDS, 2004). |
NOTE:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
|
Reference Manual |
|
|
Definitions / Abbreviations |
|
|
Model Label by MHLW |
MHLW Website （in Japanese Only） |
|
Model SDS by MHLW |
MHLW Website （in Japanese Only） |