GHS Classification Result

Chemical Name：1,1,1,2,3,3,3-Heptafluoropropane
CAS：431-89-0

Result：
ID: 21A3658
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Gas (GHS definition)
2 Flammable gases （including chemically unstable gases） Not classified - - - - Not combustible gas (IMDG (2006))
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Classification not possible - - - - No data available. The substance is classified into Division 2.2 in UNRTDG (UN3296) and Subsidiary risk is not 5.1.
5 Gases under pressure Low pressure liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. Critical temperature is 101.8 degC (Ullmanns (E) (2003)) exceeding 65 degC.
6 Flammable liquids Not applicable - - - - Gas (GHS definition)
7 Flammable solids Not applicable - - - - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Gas (GHS definition)
9 Pyrophoric liquids Not applicable - - - - Gas (GHS definition)
10 Pyrophoric solids Not applicable - - - - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable - - - - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Gas (GHS definition)
13 Oxidizing liquids Not applicable - - - - Gas (GHS definition)
14 Oxidizing solids Not applicable - - - - Gas (GHS definition)
15 Organic peroxides Not applicable - - - - Gas (GHS definition)
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - No data available.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not classified - - - - Based on no mortality in rats exposed at 800,000 ppm for 4-hour (PATTY (5th, 2001)), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Vapours） Not applicable - - - - Gas (GHS definition)
1 Acute toxicity （Inhalation: Dusts and mists） Not applicable - - - - Gas (GHS definition)
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - Based on a negative result in an inhalation mouse bone marrow micronucleus test (in vivo somatic cell mutagenicity tests) (PATTY (5th, 2001)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of a negative bacteria reverse mutation test using S. typhimurium and forward mutation test using mouse lymphoma cells (PATTY (5th, 2001)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - Although there is a report that no evidence of parental general effects, fetal toxicity, developmental effects or teratogenicity was observed in a rat developmental test by inhalation during organogenesis period (PATTY (5th, 2001)), classification was not possible due to lack of data for effects on sexual function and fertility of parental animals.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Classification not possible due to lack of data. As relevant information, there are reports that no deaths occurred when rats were exposed by inhalation to 800,000 ppm for 4-hour (no report for symptoms) (PATTY (5th, 2001)) and that exposure of 4 male and 4 female volunteers at dose levels of 1000 - 8000 ppm for 1-hour resulted in no adverse symptoms or changes in pulse, blood pressure or heart rhythm (PATTY (5th, 2001)).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - It was reported that in a 4-week inhalation exposure (6h/day) test with rats resulted in no notable toxic signs at dose levels of up to 50,000 ppm (90-day equivalence: 15,385 ppm) and that no adverse effects were observed at dose levels of up to 105,000 ppm (90-day equivalence: 32,300 ppm) (PATTY (5th, 2001)). Since the substance is a gas and the exposure levels exceed the guidance value range for Category 2, it was classified as "Not classified" based on data from inhalation exposure only.
10 Aspiration hazard Not applicable - - - - Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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