GHS Classification Result

Chemical Name：N,N-Diethylaniline
CAS：91-66-7

Result：
ID: 21A3694
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point 79 degC (closed-cup) (IUCLID (2000)) is >60 degC and <=93 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 630 degC (Incompatible Hazard Handbook of Chemicals (Tokyo Fire Department, 1997)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on LD50 values of 606, 782 and 720 mg/kg for rats (IUCLID (2000)), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on a LD50 value of >5000 mg/kg for rats (IUCLID (2000)), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on a LC50 value of 1.92 mg/L (4h) for rats (IUCLID (2000)), the substance was classified into Category 4. Since the LC50 value was higher than the saturated vapour pressure concentration (4.3E-05 mg/L), the classification criteria for mist was adopted.
2 Skin corrosion/irritation Not classified - - - - Based on a result of "slightly irritating" in a rabbit test (OECD TG404) (IUCLID (2000)), the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - Based on results of "little irritative" or "not irritating" in a rabbit Draize tests (OECD TG405) (IUCLID (2000)), the substance was classified as "Not classified".
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Although there is a report of "not sensitizing" in a guinea pig test (IUCLID (2000)), classification was not possible since the details are not clear.
5 Germ cell mutagenicity Not classified - - - - Based on a negative result in an intraperitoneal mouse bone marrow micronucleus test (OECD TG474 (GLP)) (in vivo somatic cell mutagenicity tests) (IUCLID (2000)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there is a report of a negative Ames test (NTP DB (access on Sep. 2009)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - There is a report for a developmental toxicity test by oral administration in rats during the organogenesis period (days 6 - 15 of gestation) in which maternal effects such as decrease in food consumption were observed. There were no teratogenic or embryotoxic effects (IUCLID (2000)). Classification was not possible due to lack of data for sexual function and fertility of parental animals.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system) Warning H371: May cause damage to organs (central nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a report of signs of toxicity such as cyanosis, disorders of balance and palmospasms in a rat oral test (LD50; 606 mg/kg) and a report of signs of toxicity such as ataxia and tremors in a rat inhalation test (LC50; 1.92 mg/L) (IUCLID (2000)), the substance was classified into Category 2 (central nervous system).
9 Specific target organ toxicity - Repeated exposure Category 2 (blood) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In a rat 28-day oral test (OECD TG407), haemosiderosis in the spleen and Kupffers cells, splenic extramedullary haematopoiesis and hyperaemia were observed in all treated groups (10, 50, 25 mg/kg/day, 90-day equivalence: 3 mg/kg/day and above) (IUCLID (2000)). Although these dose levels correspond to Category 1, the substance was classified into Category 2 (blood system) because of information in List 2.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 2 from its 48h-EC50 = 1.3 mg/L for Crustacea (Daphnia magna) (AQUIRE, 2010).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (Non-biodegradable, decomposition by BOD degradation rate: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1977)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information