GHS Classification Result

Chemical Name：2-Methylpropane
CAS：75-28-5

Result：
ID: 21A3704
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Gas (GHS definition)
2 Flammable gases （including chemically unstable gases） Category 1 Danger H220: Extremely flammable gas P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P381: Eliminate all ignition sources if safe to do so.
P403: Store in a well-ventilated place. 		Classified into Category 1 since the substance is classified into Division 2.1 in UNRTDG (Rev. 15, 2007) (UN1969).
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not classified - - - - The substance is classified into Division 2.1 in UNRTDG (Rev. 15, 2007) (UN1969).
5 Gases under pressure Low pressure liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. The substance is classified as "Low pressure liquefied gas" since boiling point is -11.7 degC (Ullmanns (E) (6th, 2003)) and critical temperature is 135 degC (Weiss (2nd, 1986)) exceeding 65 degC.
6 Flammable liquids Not applicable - - - - Gas (GHS definition)
7 Flammable solids Not applicable - - - - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Gas (GHS definition)
9 Pyrophoric liquids Not applicable - - - - Gas (GHS definition)
10 Pyrophoric solids Not applicable - - - - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable - - - - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Gas (GHS definition)
13 Oxidizing liquids Not applicable - - - - Gas (GHS definition)
14 Oxidizing solids Not applicable - - - - Gas (GHS definition)
15 Organic peroxides Not applicable - - - - Gas (GHS definition)
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available. Information is available that the substance is not corrosive to metals (HSDB (2008)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - No data available.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		LC50 values are 124,000 ppm/1h (4-hour equivalence: 62,000 ppm) and 52 mg/L (4-hour equivalence: 11,000 ppm) (ACGIH (2004)). Since one value corresponds to "Not classified" and the other corresponds to Category 4, the substance was classified into Category 4.
1 Acute toxicity （Inhalation: Vapours） Not applicable - - - - Gas (GHS definition)
1 Acute toxicity （Inhalation: Dusts and mists） Not applicable - - - - Gas (GHS definition)
2 Skin corrosion/irritation Not classified - - - - Based on a report that the gaseous substance does not have irritative effects on the skin in human (DFGOT vol. 20 (2003)), the substance was classified as "Not classified". As relevant information, there is a report that the liquefied substance can cause "chemical freezing" on the skin (DFGOT vol. 20 (2003)).
3 Serious eye damage/eye irritation Not classified - - - - Based on a report that the gaseous substance does not have irritative effects on the eyes in human (DFGOT vol. 20 (2003)), the substance was classified as "Not classified". As relevant information, there is a report that the liquefied substance can cause "chemical freezing" in the eye (DFGOT vol. 20 (2003)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there is a report of a negative Ames test (DFGOT vol. 20 (2003)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (heart), Category 3 (narcotic effects) Warning H371: May cause damage to organs (heart)
H336: May cause drowsiness or dizziness (narcotic effects) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		8 human volunteers exposed to the substance showed no adverse effects (Japan Society For Occupational Health (JSOH) Recommendations for allowable concentrations (1988)). However, there was a report that the substance is "cardiac calcium sensitizer2 (ACGIH (2004), PATTY (5th, 2001)) and it was reported that cardiotonic effects were observed in dogs following inhalation exposure at a concentration of 70,000 ppm for 5 min (4-hour equivalence: 10083 ppm (within the guidance value range for Category 2)) (DFGOT vol. 20 (2003)). Therefore, the substance was classified into Category 2 (heart). In addition, based on reports of "central nervous system depression" (ACGIH (2004)) and "narcotic effects" (DFGOT vol. 20 (2003)) in mouse inhalation tests, and "sensory loss" in a dog inhalation test (ACGIH (2004)), the substance was classified into Category 3 (narcotic effects). As relevant information, there is another report "the substance is a simple asphyxiant. Acute exposure may cause tachypnea and tachycardia." (PATTY (5th, 2001)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Human volunteers exposed to the substance for 2 weeks showed no adverse effects (Japan Society For Occupational Health (JSOH) Recommendations for allowable concentrations (1988)). Additionally, it was reported that there was no effect in a 90-day inhalation test in monkeys (EMEA/MRL/031 (1995)). The details are unclear and other sufficient information are not available, therefore, classification was not possible.
10 Aspiration hazard Not applicable - - - - Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information