GHS Classification Result

Chemical Name：Guanidinium nitrate
CAS：506-93-4

Result：
ID: 21A3711
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Classified into Not classified since the substance is classified into Division 5.1, PG III in UNRTDG (UN1467) though it contains chemical groups (nitrates) associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - The substance is classified as Oxidizing agents.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - The substance does not fall into upper Division 4.2, PG I since it is classified into Division 5.1 (Oxidizing substances), PG III in UNRTDG (UN1467).
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Category 3 Warning H272: May intensity fire; oxidizer P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P221: Take any precaution to avoid mixing with combustibles/...
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		The substance is solid which is classified into Division 5.1, PG III in UNRTDG (UN1467).
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		LD50 values of 1260 mg/kg bw, 989.6 mg/kg bw and 729.8 mg/kg bw for rats (IUCLID (2000)) correspond to Category 4. The substance was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on a LD0 value of >2000 mg/kg for rabbits (IUCLID (2000)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data. As relevant information, a LC0 value was >0.853 mg/L/4h for rats (IUCLID (2000)).
2 Skin corrosion/irritation Not classified - - - - Based on a result of "slight irritating "in a skin irritation test with rabbits (OECD TG404 (GLP)) where slight erythema and edema in 1/3 animals at 1-hour after application of 500 mg to the skin for 4-hour (HSDB (2008)), the substance was classified as "Not classified". As relevant information, there are reports of "highly irritating" in another rabbit test (EPA Guideline (GLP)) where 500 mg was applied to the skin for 24-hour (HSDB (2008)) and "slightly irritating" in a 24-hour application test (EPA Guideline (GLP)) (IUCLID (2000)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		In a Draize test using 6 rabbits (EPA Guideline (GLP)), conjunctival swelling and cloudy cornea were observed in at least 1 animal at periods up to 21 days and also iritis was observed at 72-hour and 14 days. Based on the rating of irritating (HSDB (2008)), the substance was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Although there is a report of "not sensitizing" in a guinea pig Buehler test (EPA Guideline (GLP)) (IUCLID (2000)), classification was not possible since this information is reported in a document in List 2 and the positive ratio is not clear.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of a negative Ames test and a negative CHL cell chromosomal aberration test (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 48h-LC50 = 23 mg/L for Crustacea (Daphnia magna) (HSDB, 2009; IUCLID, 2000).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified into Not classified since its 21d-NOEC = 2.9 mg/L (>1 mg/L) for Crustacea (Daphnia magna) (IUCLID, 2000) though its acute toxicity is Category 3 and it is not rapidly degradable (BIOWIN).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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