Chemical Name：1,3-Dichloro-1,3,5-triazine-2,4,6(1H,3H,5H)trione, sodium salt
CAS：2893-78-9

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not classified	-	-	-	-	The substance is not classified into upper class "Explosives" since the substance is classified into Division 5.1, PG II in UNRTDG (UN2465) though it contains chemical groups (N-halogen atoms) associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Not classified	-	-	-	-	Not combustible (Weiss (2nd, 1986))
8	Self-reactive substances and mixtures	Type G	-	-	-	-	Estimated to be classified into Type G since the substance is considered not to fall into upper class "Self-reactive substances and mixtures" from which it is classified into Division 5.1, PG II in UNRTDG (UN2465) though there are chemical groups (N-halogen) present in the molecule associated with explosive properties.
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	-	-	-	-	Not combustible (Weiss (2nd, 1986))
11	Self-heating substances and mixtures	Not classified	-	-	-	-	Not combustible (Weiss (2nd, 1986))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	The substance is considered to be stable against water since data are available that water solubility is 30.0 g/100 g (Ullmanns (E) 6th, 2003)) though it contains metals (Na).
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Category 2		Danger	H272: May intensity fire; oxidizer	P370+P378: In case of fire: Use ... for extinction. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P220: Keep/Store away from clothing/.../combustible materials. P221: Take any precaution to avoid mixing with combustibles/... P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	The substance is classified into Division 5.1, PG II in UNRTDG (UN2465). It is confirmed that dihydrate (CAS51580-86-0) falls into Not Classified as it is mentioned to be Non-dangerous goods in UNRTDG, Special provisions 135.
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Based on LD50 values of 735 mg/kg, 1823 mg/kg (IUCLID (2000)) and 1670 mg/kg (HSDB (2003)) for rats, the substance was classified into Category 4.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on LD50 values of >5000 mg/kg bw for rats (IUCLID (2000)) and >2000 mg/kg bw for rabbits (IUCLID (2000)), the substance was classified as "Not classified".
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Not classified	-	-	-	-	Based on a LC50 value of >50 mg/L/1h (12.5 mg/L/4h) for rats (IUCLID (2000)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification). Since the LC50 value (50 mg/L) was higher than saturated vapour pressure concentration (1.7E-13 mg/L), the test was considered to be conducted for dusts.
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	In a rabbit test by application to the skin for 24-hour, the test substance was determined to be a non-irritant to intact skin and a moderate to moderately severe irritant to abraded skin (HSDB (2003)). Additionally, it was reported that the substance was "moderate irritating" in another rabbit test (Draize test) (IUCLID (2000)). Based on these results and a report that application to wet skin or application of the solution can cause "severe irritation" (SITTIG (5th, 2008)), the substance was classified into Category 2.
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Application into the conjunctival sac of rabbits at a dose level of 10 mg showed dull irises and corneas, and erythema sufficient to make individual blood vessels not easily discernible within 1-hour. Iris congestion remained until the 7th day. The test substance was determined to be a moderately severe irritant. Additionally, the substance is classified into Xi; R36/37 in EU classification (EU-Annex I (access on Sep. 2009)). Based on these information, the substance was classified into Category 2A.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	A negative result is reported in a bone marrow chromosomal aberration test (in vivo somatic cell mutagenicity test) where rats were orally administered a related substance, monosodium cyanurate (IUCLID (2000)). However in vivo data for this substance is absent. Therefore, classification was not possible. As relevant information, from in vitro mutagenicity tests, there is a report of a negative Ames test (NTP DB (access on Sep. 2009)).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	Although there is a report that no fetal toxicity was observed when mice were administered orally during organogenesis period (teratogenic (12th, 2007)), classification was not possible due to lack of data for effects on sexual function and fertility of parental animals.
8	Specific target organ toxicity - Single exposure	Category 2 (systemic toxicity), Category 3 (respiratory tract irritation)		Warning	H371: May cause damage to organs (systemic toxicity) H335: May cause respiratory irritation (respiratory tract irritation)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell.	In a rat acute oral toxicity test (dosage 1450 - 1925 mg/kg, LD50 = 1670 mg/kg), clinical signs including emaciation, weakness, lethargy, diarrhea and necropsy findings such as irritation of the gastrointestinal tract, tissue edema, and liver and kidney congestion were observed (HSDB (2003)). In a rabbit acute oral toxicity test (dosage: 1000 - 3000 mg/kg, minimal lethal dose: 2500 mg/kg), clinical signs including prostration, coma, salivation, lacrimation, labored breathing. Necropsy findings such as liver dysfunction, irritation of the digestive tract, and lung congestion were noted (HSDB (2003)). Based on a report that the oral toxicity is apparently due to corrosive action on the stomach (HSDB (2003)), these findings are considered to be systemic toxicity caused by the strong irritation to the digestive tract. Since death occurred at dose levels within the guidance value range for Category 2 and the affected organ cannot be identified, the substance was classified into Category 2 (systemic toxicity). In addition, based on reports of irritating to the upper respiratory tract, irritating to respiratory system or some bronchospasm as signs in human exposure (HSDB (2003)), the substance was classified into Category 3 (respiratory tract irritation).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	No data available.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1 from its 48h-EC50 = 0.11 mg/L for Crustacea (Daphnia magna) (AQUIRE, 2010).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (BIOWIN).