GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Butyl lithium
CAS：109-72-8
Result：
| ID: | 21A3725 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Classification not possible | - | - | - | - | Classification is not possible since no data are available though the substance contains chemical groups (C-metals) associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 2 |
|
Danger | H225: Highly flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Classified into Category 2 since flash point -21 degC (closed-cup) (Chemical Risk Information Platform (CHRIP) (access on Sep. 2009)) is <23 degC and initial boiling point at ordinary pressure is not considered to be below 35 degC from data that initial boiling point is 80 - 90 degC (0.0001 mmHg) (Sax (11th, 2004)). |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | Classification is not possible since no data are available though the substance contains chemical groups (C-metals) associated with explosive properties present in the molecules. |
| 9 | Pyrophoric liquids | Category 1 |
|
Danger | H250: Catches fire spontaneously if exposed to air |
P302+P334: IF ON SKIN: Immerse in cool water/wrap in wet bandages. P370+P378: In case of fire: Use ... for extinction. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P222: Do not allow contact with air. P280: Wear protective gloves/protective clothing/eye protection/face protection. P422: Store contents under ... |
Classified into Category 1 since butyl lithium is pyrophoric in presence of air (Hommel (1996)). The following information is available in Hommel that "Concentrated butyllithium is pyrophoric and explodes on contact with water. After butyllithium solution dried up, pyrophoric hollow-substance is left." and "International transportation is made exclusively in the form of hydrocarbon solution. In this case, pentane, hexane or heptane is used. These solutions of butyllithium are easy to ignite, but are no more pyrophoric." (Hommel (1996)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | - | The substance is classified into Division 4.2, PG I in UNRTDG and is Pyrophoric liquids. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Category 1 |
|
Danger | H260: In contact with water releases flammable gases which may ignite spontaneously |
P231+P232: Handle under inert gas. Protect from moisture. P335+P334: Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. P370+P378: In case of fire: Use ... for extinction. P402+P404: Store in a dry place. Store in a closed container. P223: Keep away from any possible contact with water, because of violent reaction and possible flash fire. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Classified into Category 1 since the substance contains metals (Li) and the information is available that is "Concentrated butyl lithium is pyrophoric and explodes on contact with water." (Hommel (1996)) and "It may ignite since it mixes slightly with water and floats on water surface but reacts with water intensively generating heat." (Hommel (1996)). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine or chlorine |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available. [For health hazards, refer also to other lithium compounds]. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. As information in a document in List 3, there is a report that contact can irritate and burn the skin (HSFS (2002)). |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. As information in a document in List 3, there is a report that contact can irritate and burn the eyes (HSFS (2002)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Category 1A |
|
Danger | H360: May damage fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
There is no available data for the substance. However, lithium is classified as a teratogenic agent in "Chemically Induced Birth Defects" (Birth Defects 3rd. (2000)). Based on case reports of congenital heart disease in pregnant women taking lithium, teratogenicity for human is suggested in "Catalog of Teratogenic Agents" (Teratogenic 12th (2007)). Based on this information, the substance was classified into Category 1A. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No data available. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |