GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
CAS：13909-09-6
Result：
| ID: | 21A3730 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Classification not possible | - | - | - | - | Classification is not possible since no data are available though the substance is possible to be classified into "Explosives" from which it contains chemical groups (N-N and N-O) associated with explosive properties present in the molecules and oxygen balance is -174.38 which is >-200. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Classification not possible | - | - | - | - | No data available. |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | Classification is not possible since no data are available though there are chemical groups associated with explosive properties present in the molecules. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to solid (melting point <= 140 degC) substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | No data available. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | Classification not possible due to lack of data. As relevant information, a LD50 value of 49.9 mg/kg for mice (RTECS (2008)) and the details are unknown. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Category 2 |
|
Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on a positive result in a mouse micronucleus test (in vivo test) (RTECS (2008); Mutat. Res. 286 101-109 (1993)), the substance was classified into Category 2. As relevant information, there is a report of a positive unscheduled DNA synthesis test (RTECS (2008); Cancer Res 35, 2420-2425 (1975)). From in vitro mutagenicity tests, there is a report of a positive Ames test (RTECS (2008); Journal of the National Cancer Institute, vol. 65, p. 149). |
| 6 | Carcinogenicity | Category 1A |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the classification of "Group 1" (there is sufficient evidence of carcinogenicity in humans) in IARC (IARC vol. 100A (2008), suppl. 7 (1987)) and "Known to be Human Carcinogens" in NTP (NTP RoC (2005)), the substance was classified into Category 1A. |
| 7 | Reproductive toxicity | Category 1B |
|
Danger | H360: May damage fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on a report of "fetal abnormalities if pregnancy occurs while taking this drug" as a common side effect (PDR 64 edition (2010)), the substance was classified into Category 1B. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (bone marrow), Category 2 (systemic toxicity) |
|
Danger Warning |
H370: Causes damage to organs (bone marrow) H371: May cause damage to organs (systemic toxicity) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. |
In Physicians' Desk Reference (PDR 64 edition (2010)), there are reports of nausea, vomiting, myelosuppression (decreased white blood cell count and platelet count) in the section on Common Side Effects. Based on the data, the substance was classified into Category 1 (bone marrow). In addition, there are reports of fatigue, sores in mouth or on lips, feeling disoriented, difficulty walking, blurred vision, change in vision, liver and kidney problems, and scarring of lung tissue in the section on Rare Side Effects. Since it is unclear whether they are acute effects, the substance was classified into Category 2 (systemic toxicity). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (bone marrow), Category 2 (liver, kidney, lung, nervous system) |
|
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (bone marrow) H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney, lung, nervous system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
In Physicians' Desk Reference (PDR 64 edition (2010)), there are reports of nausea, vomiting, myelosuppression (decreased white blood cell count and platelet count) in the section on Common Side Effects. Based on the data, the substance was classified into Category 1 (bone marrow). In addition, there are reports of fatigue, sores in mouth or on lips, feeling disoriented, difficulty walking, blurred vision, change in vision, liver and kidney problems, and scarring of lung tissue in the section on Rare Side Effects. Since it is unclear whether they are secondary effects, the substance was classified into Category 2 (liver, kidney, lung, nervous system). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
|
Reference Manual |
|
|
Definitions / Abbreviations |
|
|
Model Label by MHLW |
MHLW Website （in Japanese Only） |
|
Model SDS by MHLW |
MHLW Website （in Japanese Only） |