GHS Classification Result

Chemical Name：Cobalt (II) sulfate
CAS：10124-43-3

Result：
ID: 21A3758
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Not combustible (ICSC (J) (2001))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Not combustible (ICSC (J) (2001))
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC (J) (2001))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Information is available that water solubility is 38.3 g/100 g H2O (25 degC) (Lide (88th, 2008)) though it contains metals (Co).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - Not oxidizing (IUCLID (2000))
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on LD50 values of 510 mg/kg and 424 mg/kg for rats (ATSDR (2004)), the substance was classified into Category 4. [For health hazards, refer also to cobalt (II) chloride (CAS: 7646-79-9)].
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		There is a report that bronchial asthma was reported in workers exposed to various forms of cobalt (CICADs 69 (2006)). Additionally, cobalt compounds are classified into R42/43 in EU classification (EU-Annex I (2009)) and are classified into Category 1 for respiratory tract sensitizer in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations (2009)). Therefore, the substance was classified into Category 1.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		There is a report that 10/25 healthy volunteers were sensitized to cobalt sulfate in a maximization test (DFGOT vol. 23 (2007)). Additionally, in Japan Society For Occupational Health (JSOH), cobalt is classified into Category 1 for skin sensitizer, but the following statement is found: "the substance and its compounds are included in the list of sensitizers, but all of them were recognized as sensitizers." (Recommendations for allowable concentrations (2008)). Therefore, the substance was classified into Category 1. As relevant information, the substance is classified into R42/43 in EU classification (EU-Annex I (2009)).
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there is a report of a weakly positive response in an Ames test with cobalt sulfate heptahydrate (CAS 10026-24-1) (NTP TR471 (1998)).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since cobalt and cobalt compounds are classified into "Group 2B" in IARC (IARC 52 (1991)) and are classified into Category 2B in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations (2008)), the substance was classified into Category 2. It was concluded that there was clear evidence of carcinogenic activity in rat and mouse 2-year inhalation tests, based on increased incidences of alveolar/bronchiolar neoplasms in both species (NTP TR471 (1998)).
7 Reproductive toxicity Classification not possible - - - - In oral tests in rats, mice and rabbits exposed to cobalt sulfate during gestation, no fetal developmental toxicity was observed except at the high dose level at which maternal death was observed (CICAD 69 (2006)). However, classification was not possible due to lack of data for effects on sexual function and fertility of parental animals exposed before mating. As relevant information, the substance is classified into Category 2; R60 in EU classification (EU-Annex I (2009)).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available. As relevant information, there is the following information for cobalt (II) chloride: In a rat oral test (by gavage), depression of spontaneous activity, muscle tone and respiration were observed at 4.25 mg/kg (ATSDR (2004)). Undesirable effects in humans include retrosternal chest pain, tinnitus, nausea and vomiting, nerve deafness, thyroid hyperplasia with tracheal compression, myxedema and fatigue (HSDB (2004)). Ingestion of a solution of the substance depressed the production of erythrocytes in children and produced cyanosis, coma and death (HSDB (2004)).
9 Specific target organ toxicity - Repeated exposure Category 1 (heart, respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (heart, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the early to mid-1960s, breweries in the United States and Europe added the substance to beer as a foam stabilizer. Several tests reported lethal cardiomyopathy in people who consumed large quantities of beer because of cobalt sulfate ingestion (CICADs 69 (2006)). Based on this information, the substance was classified into Category 1 (heart). In 13-week inhalation tests in rats and mice (0, 0.3, 13, 10 and 30 mg/m3), both rats and mice developed squamous metaplasia of the larynx (>=0.3 mg/m3), chronic inflammation of the larynx, nose and lung (0.3 - 1 mg/m3), and more severe effects at higher exposures (>30 mg/m3) (CICADs 69 (2006)). Since these effects were observed at dose levels within the guidance value range for Category 1, the substance was classified into Category 1 (respiratory system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 2 from its 96h-LC50 = 3.6 mg/L for fish (Fathead minnow) (CICAD 69, 2006).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified into Not classified since its bioconcentration potential is low (BCF <=37 (Cyprinus carpio, 6 weeks)), (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1998).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
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