GHS Classification Result

Chemical Name：Decahydronaphthalene
CAS：91-17-8

Result：
ID: 21A3763
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified into Category 3 since flash point 58 degC (closed-cup) (Merck (14th, 2006)) is >=23 degC and <=60 degC. The substance is classified into Class 3, PG III in UNRTDG (UN1147).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 250 degC (Sax (11th, 2004)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance does not contain oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on a LD50 value of 4170 mg/kg for rats (PATTY (5th, 2001)), the substance was classified into "Not classified" in JIS classification (correspond to Category 5 in GHS classification).
1 Acute toxicity （Dermal） Not classified - - - - Based on a LD50 value of 5900 mg/kg for rabbits (PATTY (5th, 2001)), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		LC50 values (4h) of 500 ppmV (PATTY (5th, 2001)) and 710 ppmV (NTP TR 513 (2005)) for rats correspond to Category 2 and Category 3, respectively. The category with higher hazard was adopted and the substance was classified into Category 2. Since the LD50 values are lower than 90% of saturated vapour pressure concentration (3026 ppm), the classification criteria of gas was adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a result that the substance showed a strong irritant effect on the skin and caused necrosis by application to the skin of rabbits for 4-hour (OECD TG404), it was concluded to be corrosive with a skin primary irritation index of 7.5/8.0 (BUA 218 (1998)). The substance was classified into Category 1.
3 Serious eye damage/eye irritation Not classified - - - - Based on a result that in a rabbit eye irritation test (OECD TG405), no irritant effect on the cornea or iris was observed and the marked hyperemia and swelling of the conjunctiva had completely disappeared after 6 and 8 days, it was concluded that the substance was not irritating with an eye irritation index of 3.5/110 (BUA 218 (1998). The substance was classified as "Not classified". As relevant information, there is a report that dropping the substance on rabbit eyes caused no injury (HSDB (2004)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - Based on a result of "not-sensitizing" (positive ratio: 0%) in a guinea pig maximization test (OECD TG406) (BUA 218 (1998)), the substance was classified as "Not classified".
5 Germ cell mutagenicity Not classified - - - - Based on negative results in a mouse peripheral blood micronucleus test by 13-week inhalation exposure (in vivo somatic cell mutagenicity test) (NTP DB (aaccess on Nov. 2009)) and in an in vitro chromosomal aberration test using Chinese hamster lung fibroblast cells ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Dec. 2000)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of negative reverse mutation tests using S. typhimurium ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Dec. 2009), NTP DB (access on Dec. 2009)) and a negative mouse lymphoma cell gene mutation test (BUA Report No.218 (1998)). [Based on expert's decision, weakly positive result for males in the mouse micronucleus test is considered not to be biologically significant because of slight increase (2 times control value) and negative result for females.]
6 Carcinogenicity Classification not possible - - - - In rat and mouse 2-year inhalation tests (NTP TR513 (2005)), survival of exposed groups was similar to that of the control groups and incidences of renal tubule adenoma and pheochromocytoma of the adrenal gland were significantly increased for male rats only. However, the development of these neoplasms was likely related to alpha2u-globulin nephropathy specific to male rats, which may not be applicable as an indication of human carcinogenicity. In addition to these findings, marginally increased incidences of hepatocellular and uterine neoplasms were observed in female mice. Classification was not possible based on the absence of sufficient information for judging the carcinogenicity.
7 Reproductive toxicity Classification not possible - - - - In a oral test in mice in which the substance was administered on days 6 - 13 of gestation, there were no effects in the offspring developmental parameters including birth weight, neonatal growth and survival to postnatal day 3 at dose levels producing maternal mortality (NTP TR513 (2005)). However, classification was not possible due to lack of data for effects on sexual function and fertility of parental animals.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on reports that the vapour can irritate the respiratory system (BUA Report 269 (2006)) and that breathing the substance can irritate the nose and throat (HSFS (2002)), the substance was classified into Category 3 (respiratory tract irritation). As relevant information, there is a report that vapour exposures in guinea pigs or dropping on rabbit eyes caused cataracts (PATTY (5th, 2001), HSDB (2004)). Test conditions such as dose level or detailed results are unclear for both the guinea pig vapour and the rabbit eye reports.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In mouse inhalation tests, incidences of centrilobular cytomegaly of the liver were increased in males exposed to 0.14 - 2.26 mg/L (vapour, 6h/day) for 14 weeks (NTP TR513 (2005)), and incidences of hepatocyte vacuolization of the liver were increased in females exposed to 0.028 - 0.283 mg/L for 90 days or 0.287 - 1.435 mg/L (24h/day) for 30 days (NTP TR513 (2005), BUA Report 218 (1998)). Since these effects were observed at dose levels within the guidance value range for Category 1, the substance was classified into Category 1 (liver). In rat and mouse inhalation tests, the exposure to 0.287 - 1.435 mg/L (6h/day) for 30 day caused concentration-dependent histopathological changes in the trachea, bronchi and alveoli (formation of hyaline droplet on the tracheal epithelium, loss or proliferation of cells, exudate, increased incidence of type II alveolar epithelial cells in tracheobronchial epithelium). Additionally, in a guinea pig inhalation test, exposure at the same concentration for the same period caused irritation to alveoli with multifocal pneumonia, alveolar wall thickening with exudate (NTP TR513 (2005), BUA Report 218 (1998)). Since these effects were observed at dose levels within the guidance value range for Category 1, the substance was classified into Category 1 (respiratory system). Based on effects in both liver and respiratory system, the substance was classified into Category 1 (liver, respiratory system). As relevant information, in rat tests, degeneration in renal tubules with alpha2u-globulin accumulation and hyaline droplet accumulation was observed in the kidney of male rats (NTP TR513 (2005)), however, the lesion was the alpha2u-globulin nephropathy specific to male rats which may not be considered as a human risk. Therefore, this result was not used as the basis of classification. Additionally, it was reported that excessive exposure to high concentrations caused numbness, nausea, headache, and vomiting in human (PATTY (5th, 2001).
10 Aspiration hazard Category 1 Danger H304: May be fatal if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since the substance is a hydrocarbon with kinematic viscosity of 1.9 mm2/s (approx. 25 degC) and is noted that aspiration into the lung may result in chemical pneumonitis (ICSC (2004)), the substance was classified into Category 1.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Classification not possible due to lack of data.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information