NITE - Chemical Management Field

GHS Classification Result

Chemical Name：Bismuth
CAS：7440-69-9

Result：


ID:	21A3764
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2009
Reference Manual:	GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	-	-	-	-	Information is available that is "When bismuth is heated in air it burns with a blue flame, forming yellow fumes of the oxide." (Lide (2008)), and the substance is combustible at high temperature. The substance is classified into Not classified in GHS classification since the test is required for the product to be judged.
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	-	-	-	-	Judged not to be pyrophoric since the substance is considered to exist stably in nature from the information that bismuth is not very reactive (Ullmanns (E) (6th, 2003))
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	No data available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	Judged not to be pyrophoric since the substance is considered to exist stably in nature from the information that bismuth is not very reactive (Ullmanns (E) (6th, 2003)).
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	-	-	-	-	Inorganic compounds containing no oxygen and halogen atoms
15	Organic peroxides	Not applicable	-	-	-	-	Inorganic compound
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on a LD50 value of 5000 mg/kg bw for rats (RTECS (2009); the original literature: Encyclopedia of Toxicology: Reference Book, Elsevier, vol. 312, 2005), the substance was classified into "Not classified". [For health hazards, refer also to other bismuth compounds].
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of a negative Ames test and a weakly positive chromosomal aberration test (J Occup Health, 2009; 51 (6): 498-512).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	Although there is a report of increase in embryonic mortality and lagging in fetal development for rats and mice (HSDB (2002)), the details are not clear. Classification was not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system, kidney, articulation of the bone)		Danger	H370: Causes damage to organs (nervous system, kidney, articulation of the bone)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	It was reported that common toxic effects that were attributed to bismuth and bismuth compounds in humans are encephalopathy, nephropathy, osteoarthropathy, gingivitis, stomatitis and colitis, and inorganic bismuth compounds cause neurotoxicity (PATTY (5th, 2001)). Additionally, there is a report that clinical manifestations of acute bismuth intoxication are similar to those caused by mercury and lead: neurological abnormalities which include encephalopathy, and renal dysfunction with nephrotic syndrome (PATTY (5th, 2001)). In a death case, examination of the deceased showed necrosis of the cerebral and cerebellar cortex (HSDB (2002)). In a second case, acute renal failure was found following ingestion (HSDB (2008)). Based on all information, the substance was classified into Category 1 (nervous system, kidney, bone, joint).
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, articulation of the bone, kidney)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system, articulation of the bone, kidney)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	It was reported that for the substance the main target organs are the brain, kidney and bone. There are numerous cases in which chronic exposure caused varying neurologic symptom before on set of encephalopathy (PATTY (5th, 2001)). Additionally, there are numerous reports that osteoarthropathy, pathological fractures or osteoporosis in combination with osteomalacia were observed after chronic ingestion or treatment with the substance (PATTY (5th, 2001)). Based on this information for humans, the substance was classified into Category 1 (nervous system, bone, joint, kidney).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Classification not possible	-	-	-	-	Classification not possible due to lack of data.
11	Hazardous to the aquatic environment （Long-term）	Classification not possible	-	-	-	-	Classification not possible due to lack of data.
12	Hazardous to the ozone layer	Classification not possible	-	-	-	-	This substance is not listed in Annexes to the Montreal Protocol.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）