GHS Classification Result

Chemical Name:Bismuth (III) nitrate
CAS:10361-44-1

Result:
ID: 21A3766
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - Classification is not possible since no data are available though the substance contains chemical groups (nitrate) associated with explosive properties present in the molecules and oxygen balance is -24.3.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Classification not possible - - - - Classification is not possible since no data are available though there are chemical groups (nitrate) associated with explosive properties present in the molecules.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - The substance is considered not to cause dangerous reaction with water from the information that it dissolves in water containing nitric acid (Merck) though it contains metalloids (Bi).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available. Inorganic nitrate may be classified into Division 5.1 (Oxidizing substances), PG II or III in UNRTDG (UN1477: NITRATES, INORGANIC, N.O.S.). This falls into Category 2 or 3. Classification should be made by conducting the designated test.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Classification is not possible since no data are available though the substance is solid (melting point <= 55 degC).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - Classification not possible due to lack of data. As relevant information, a LD50 value is 4 g/kg for rats (RTECS (2007)). [For health hazards, refer also to other bismuth compounds].
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, kidney, articulation of the bone) Danger H370: Causes damage to organs (nervous system, kidney, articulation of the bone) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was reported that common toxic effects that were attributed to bismuth and bismuth compounds in humans are encephalopathy, nephropathy, osteoarthropathy, gingivitis, stomatitis and colitis, and inorganic bismuth compounds cause neurotoxicity (PATTY (5th, 2001)). Additionally, there is a report that clinical manifestations of acute bismuth intoxication are similar to those caused by mercury and lead: neurological abnormalities which include encephalopathy, and renal dysfunction with nephrotic syndrome (PATTY (5th, 2001)). Based on this information, the substance was classified into Category 1 (nervous system, kidney, bone, joint).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, articulation of the bone, kidney) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, articulation of the bone, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Since it was reported that common toxic effects that were attributed to bismuth and bismuth compounds in humans are encephalopathy, nephropathy, osteoarthropathy, gingivitis, stomatitis and colitis, and inorganic bismuth compounds cause neurotoxicity (PATTY (5th, 2001)), the substance was classified into Category 1 (nervous system, bone, joint, kidney). One case history reported a 69-year-old German patient who developed depression, lack of concentration, nervousness and panic attacks after the intake of the substance at 8 g/day for a period of 3 weeks. After 12 months, he developed difficulty with short- and long-term memory, difficulty in reading and writing, tremor and dysarthria. After 15 months, the syndrome progressed into full myoclonic Bi encephalopathy. (PATTY (5th, 2001)). There are numerous cases that report the neurotoxicity of bismuth compounds, the clinical cases usually include Bi encephalopathy (PATTY (5th, 2001)). In addition, there is a report that the symptoms of chronic toxicity in humans consist of decreased appetite, rheumatic pain, diarrhea, fever, foul breath, gingivitis and dermatitis (HSDB (2002)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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