GHS Classification Result （Revision of the past classification result）
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Acetone cyanohydrin
CAS：75-86-5
Result：
| ID: | 21B3002 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 4 | - | Warning | H227: Combustible liquid |
P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Flash point 74 degC (ICSC (1998)) is >60 degC and <=93 degC. |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Auto-ignition point is 685 degC (Hommel (1996)) exceeding 70 degC. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, C, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 2 |
|
Danger | H300: Fatal if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on a LD50 value of 15.8 mg/kg for rats (ACGIH (2001)), the substance was classified into Category 2. |
| 1 | Acute toxicity （Dermal） | Category 1 |
|
Danger | H310: Fatal in contact with skin |
P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
LD50 values of 16, 150 and 850 mg/kg for rabbits (OECD TG402, ECETOC JACC 53 (2007)) correspond to Category 1, 2 and 3, respectively. A LD50 value of 140 mg/kg for rats (PATTY (5th, 2001)) corresponds to Category 2. The category with higher hazard was adopted and the substance was classified into Category 1. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 1 |
|
Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on mortalities of 2/6 at 62.5 ppm and 6/6 at 125 ppm after 4-hour inhalation exposure to rats (ACGIH (2001)), the substance was classified into Category 1. Since saturated vapour pressure concentration is 411 ppmV, the test was considered to be conducted for vapour with almost no included mists and classification criteria for gas was adopted. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on a negative result in a bone marrow chromosomal aberration test by oral administration to rats (in vivo somatic cell mutagenicity test) (CICAD 61 (2004)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of negative Ames tests (ECETOC JACC 53 (2007), NTP DB (access on Apr. 2009)) and a negative CHO cell mutation test (CICAD 61 (2004)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Not classified | - | - | - | - | In fertility tests in rats, after inhalation exposure for 69 days (male) or 21 days (female), the males and females were mated to untreated females and males, respectively. Although a slight decreased body weight was observed in the high dose group, there were no exposure-related effects on fertility, pregnancy rates or fetal development (ECETOC JACC 53 (2007)). In a developmental toxicity test by oral administration to rats during organogenesis period, no significant differences from controls were observed for any fetal developmental parameter at a dose in which maternal general toxicity (reduction in body weight gain) was noted and no adverse effects were reported on fetal development including teratogenicity (ECETOC JACC 53 (2007)). Since no fertility toxicity or developmental toxicity was observed, the substance was classified as "Not classified". |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system) |
|
Danger | H370: Causes damage to organs (central nervous system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
There are many human case reports of accidental exposure (mainly dermal). Symptoms of exposure included lost of consciousness, comatose, dyspnea, and tonic-clonic convulsions. In some cases, exposed individuals died (ACGIH (2001)). Since lost of consciousness and tonic-clonic convulsions were reported and there is a report that acute exposure may cause CNS stimulation (HSDB (2005)), the substance was classified into Category 1 (central nervous system). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver, kidney) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (liver, kidney) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
When 5 mg/animal was administered orally to rats twice a week for 3 - 8 months (the dose level is estimated to be 12.5 mg/kg for a body weight of 400 g and the daily dose level is calculated to be approximately 4.1 mg/kg/day because of twice a week administration), decreases of total protein, glycoprotein and A/G ratio, pyknosis, anisokaryosis and fatty degeneration of hepatocyte as well as kidney lesions were found (ACGIH (2001), PATTY (5th, 2001)). Based on this report, the substance was classified into Category 1 (liver, kidney). In addition, similar findings were found in livers and kidneys in a rat test by inhalation exposure at concentration of 102 mg/L twice a week for 3 - 8 months ACGIH (2001)). Results of the inhalation test supported the results of the oral exposure test. There were no significant toxic effects in 4-week and 14-week inhalation tests in rats (highest concentration: approximately 0.21 mg/L) (CICAD 61 (2004)). The lack of any significant toxic effect in this test is attributed to the lower concentrations tested. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1 from its 48h-EC50 = 0.13 mg/L for Crustacea (Daphnia magna) (SIDS, 2007). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (BOD degradation rate: 0 - 55% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1986)). |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |