NITE - Chemical Management Field

GHS Classification Result （Revision of the past classification result）

Chemical Name：Phosphorus trichloride
CAS：7719-12-2

Result：


ID:	21B3009
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2009
Reference Manual:	GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	-	-	-	-	Not combustible (Hommel (1996))
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	-	-	-	-	Not combustible (Hommel (1996))
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Not classified	-	-	-	-	Not combustible (Hommel (1996))
12	Substances and mixtures which, in contact with water, emit flammable gases	Classification not possible	-	-	-	-	Classification is not possible since no data are available though the substance contains phosphorous. It is considered that the substance is outside of the range of combustible risk since it is not classified into Division 4.3 in UNRTDG though the information is available that the substance violently reacts with water "forming combustible phosphine together with the generation of heat which may spontaneously ignite and explode" (NFPA (13th, 2006), "forming combustible diphoshane" (Bretheric (7th, 2007)).
13	Oxidizing liquids	Classification not possible	-	-	-	-	Classification is not possible since no data are available though the substance contains chlorine.
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Inorganic compound
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 2		Danger	H300: Fatal if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on LD50 values of 18 mg/kg, 200 mg/kg and 550 mg/kg for rats (SIDS (access on April. 2009)), the lowest value (18 mg/kg) was adopted and the substance was classified into Category 2.
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	Classification not possible due to lack of data. As relevant information, LD50 values are >1000 mg/kg and >250 mg/kg for rabbits (SIDS (access on April. 2009)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on a LC50 value of 104 ppm/4h for rats (ACGIH (2001)), the substance was classified into Category 4. Since the test was conducted at lower than 90% of saturated vapour pressure concentration, the classification criteria for gas was adopted.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Category 1A		Danger	H314: Causes severe skin burns and eye damage	P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	Based on results of "highly corrosive" following application for 60 seconds in a rabbit test (SIDS (2009)) and "irritating or corrosive" in a second rabbit test (SIDS (2009)), the substance was classified into Category 1A. As relevant information, the substance is classified into C; R35 in EU classification.
3	Serious eye damage/eye irritation	Category 1		Danger	H318: Causes serious eye damage	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician.	Based on results of "corrosive" in a rabbit test (SIDS (2009)) and "irreversible necrosis causing loss of vision" in a second rabbit test (SIDS (2009)), the substance was classified into Category 1.
4	Respiratory sensitization	Classification not possible	-	-	-	-	There is a report that symptoms included irritation of the pharynx and asthmatic bronchitis which occurred 1 to 8 weeks after exposure in workers employed in the production of the substance (ACGIH (2001)). In addition, although there are reports of an impairment of lung function and asthmatic bronchitis after inhalation exposure to humans (SIDS (2009)), these data are not sufficient as evidence of induction of specific respiratory hypersensitivity, therefore, classification was not possible due to lack of other data.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative results in a human peripheral lymphocyte chromosomal aberration test (in vivo somatic cell mutagenicity test) and a bone marrow micronucleus test by intraperitoneal administration to mice (in vivo somatic cell mutagenicity test) (SIDS (2009)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there is a report of a negative Ames test (SIDS (2009)).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	There is a report that skeletal development in treated fetuses was retarded but no other effects were observed in a rat oral test (organogenesis period: days 5 - 16 of pregnancy) (SIDS (2009)). Since there is no data for effects on sexual function and fertility, classification was not possible due to lack of sufficient data.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system)		Danger	H370: Causes damage to organs (respiratory system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	The symptoms in 23 workers following inhalation exposure of the substance (1.8 - 27 ppm) included burning eyes and throat, irritation of pharyngeal mucous membranes, and mild bronchitis. These changes occurred within 2 to 6-hour following exposure (ACGIH (2001)). In a spill incident during a filling operation, 17 exposed individuals experienced dyspnea, vomiting and decrements in vital capacity (ACGIH (2001)). Based on these reports, the substance was classified into Category 1 (respiratory system).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (respiratory system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Following repeated exposure the following symptoms were observed in exposed individuals: irritation of the pharynx, coughing and asthmatic bronchitis. These symptoms occurred 1 to 8-week after exposure. In workers who had at least 1 year of exposure, emphysema was sometimes found (ACGIH (2001)). After 4-week of inhalation exposure to rats, inflammation and squamous metaplasia of respiratory epithelium were observed at a concentration of 10 ppm/6h (0.0561mg/L/6h, 90-day equivalence: 0.019 mg/L/6h) which is within the guidance value range for Category 1 (SIDS (access on Apr. 2009)). Based on these reports, the substance was classified into Category 1 (respiratory system).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 3	-	-	H402: Harmful to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Classified into Category 3 from its 72h-ErC50 = 33 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2006).
11	Hazardous to the aquatic environment （Long-term）	Not classified	-	-	-	-	Classified into Not classified since the toxicity is mitigated in environmental water by buffer action though it is considered to be a factor of toxicity that water solution becomes strongly acidic.
12	Hazardous to the ozone layer	Classification not possible	-	-	-	-	This substance is not listed in Annexes to the Montreal Protocol.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）