GHS Classification Result （Revision of the past classification result）

Chemical Name：Butyl acetate
CAS：123-86-4

Result：
ID: 21B3031
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point 22 degC (closed-cup) (ICSC (2003)) is <23 degC and initial boiling point 126 degC (ICSC (2003)) is >35 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 422 degC (Ullmanns (E) (6th, 2003)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Not classified - - - - Steel and aluminum can be used for containers (Hommel (1996)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on a LD50 value of 14.13 g/kg for rats (ACGIH (2001)), the substance was classified into "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Based on LD50 values of >5 g/kg and >20 mL/kg (>17.6 g/kg) for rabbits (ACGIH (2001)), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a LC50 value of 2000 ppm for rats (ACGIH (2001)), the substance was classified into Category 3. Since the value is lower than 90% of saturated vapour pressure concentration (15,043 ppmV), the test was considered to be conducted for vapour with almost no included mists and classification criteria for gas was adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on LC50 values of 156 ppm/4h (0.74 mg/L/4h) and 391 ppm/4h (1.86 mg/L/4h) for rats (the tests were conducted for mists) (ACGIH (2001)), the category with higher hazard was adopted and the substance was classified into Category 3.
2 Skin corrosion/irritation Not classified - - - - In a rabbit skin irritation test (Draize test), the substance was a mild irritant, i.e., "the least visible capillary injection" (ACGIH (2001)). Additionally, there are reports of no irritating in another rabbit test and a human test with 4% solutions (IUCLID (2000)). Based on these data, the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		In a test where 0.1 mL undiluted substance was applied into the eyes of rabbits (ECETOC TR48 (2) (1998)), maximum irritation was observed at 24-hour after application, at which time the mean scores were <1 for corneal opacity, 0 for iris, 1 for conjunctivae redness and <1 for chemosis. Since the MMAS was less than 30 and the effects were almost reversed within 7 days, the substance was classified into Category 2B. In other rabbit tests, results of no irritating or mild irritating were reported (ACGIH (2001), IUCLID (2000)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - There is a result of "not sensitizing" in a guinea pig maximization test (ACGIH (2001)). In repeated insult patch tests with 50 subjects, no subject was sensitized (ACGIH (2001)). The substance was classified as "Not classified".
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of negative Ames tests (ACGIH (2001), JECFA (1998)), a negative E. coli aneuploidy test (ACGIH (2001)) and a negative Chinese hamster fibroblast chromosomal aberration test (ACGIH (2001)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In inhalation tests in rats and rabbits by exposure during the gestation or organogenesis period, food consumption was reduced. Additionally, in rats, the body weight and fetal length were reduced and the incidence of abnormally formed ribs (wavy, fused, branched) was increased. In rabbits, the incidence of morphological variations of the gall bladder and other anomalies (retinal folds, unsymmetrically fused breastbone) was increased. However, as these findings are generally regarded as variations and not as malformations, no adverse effects on fetal development including teratogenicity were observed (DFGOT vol. 19 (2000)). In a rat test by inhalation exposure during the 3 weeks before mating until organogenesis period, there were no adverse effects on parental sexual function and fertility (DFGOT vol. 19 (2000)). Since only females were exposed to the substance in these tests, classification as "Not classified" was questionable, therefore classification was not possible.
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system, central nervous system) Warning H371: May cause damage to organs (respiratory system, central nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In an aerosol inhalation test in rats, congestion, alveolar hemorrhage, sloughing of the bronchiolar mucosa, necrosis of the alveolar epithelial cells, and pulmonary edema were observed at a dose level of 540 ppm/4h (2.57 mg/4h) (ACGIH (2001)). Based on this result, the substance was classified into Category 2 (respiratory system). In addition, it was reported that a worker who had been exposed to a solvent mixture composed of the substance (48%), xylene (26%) and ethylene glycol acetate (26%), experienced drowsiness with slight motor impairment (ACGIH (2001)). There is a report that very high concentration exposure may cause unconsciousness (Japanese journal of industrial health vol. 36 (1994)). In rats, after inhalation exposure to the vapour, ataxia, and narcosis were observed at 6867 ppm/4h (32.6 mg/L/4h) and decreased motor activity and hypoactivity were observed at 3000 - 6000 ppm/6h (17.5 - 34.9 mg/L/4h) (ACGIH (2001)). In mice, after inhalation exposure of 8000 ppm for 20 minutes (11 mg/L/4h), abnormal posture, decrease in arousal level, tonic/clonic movement, and delay of righting reflex were observed (PATTY (5th, 2001)). Although the neurologic symptoms observed in the worker resolved fast and was not serious, the symptoms in animals were observed at dose levels within the guidance value range of Category 2. Based on the animal results, the substance was classified into Category 2 (central nervous system). In human subjects, exposures to concentrations of 300 ppm for 2 - 5 minutes cause irritation of the pharynx (Japanese journal of industrial health vol. 36 (1994)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a 14-week inhalation test in rats exposed to concentrations of 500 - 15,000 ppm/6 h (2.38 - 7.13 mg/L/6h), transient signs of sedation and hypoactivity were observed but histological examination of the central and peripheral nervous systems did not reveal any differences from the control. The NOEL was reported to be 500 ppm (2.38 mg/L/6h) (DFGOT vol. 19 (2000)). However, classification as "Not classified" is questionable due to no data from specific investigations to evaluate the neurotoxic potential of the substance. For humans, there are epidemiological tests showing that symptoms such as dizziness and vertigo, chest pain, headaches, and nausea or neurobehavioral effects are associated with occupational exposure (ACGIH (2001), PATTY (5th, 2001)). The human data for the substance are difficult to evaluate since the reports deal with solvent mixtures rather than with exposure to the substance alone (ACGIH (2001)). As with the case with animal data, classification was not possible due to lack of sufficient data.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 96h-LC50 = 18 mg/L for fish (Fathead minnow) (CICAD64, 2005).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified into Not classified since it is rapidly degradable (BOD degradation rate: 98% (SIDS, 2009)) and low bioaccumulative potential is estimated (log Kow = 1.78 (PHYSPROP Database, 2009)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information