GHS Classification Result (Revision of the past classification result)

Chemical Name:O,O-Dimethyl S-[(4-oxo-1,2,3-benzotriazin-3(4H)-yl)methyl]phosphorodithioate, (Azinphos-methyl)
CAS:86-50-0

Result:
ID: 21B3038
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - Classification is not possible since no data are available though the substance may be classified as "Explosives" from which it contains chemical groups associated with explosive properties present in the molecules and oxygen balance is -30.25 which is >-200.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Classification not possible - - - - Classification is not possible since no data are available though there are chemical groups associated with explosive properties present in the molecules (but not chemical groups associated with self-reactive properties).
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Not react with water (Weiss (2nd, 1985)).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
LD50 values are 4.4, 4.6, 5.6, 7.4, 11, 12.2, 13 and 19.5 mg/kg (ACGIH (2002)), 4.4, 4.6, 6.4, 6.4, 6.7, 7.1, 9.1, 9.7, 9.7, 10, 11, 12.8, 15.6, 16, 16.75, 17.25, 19, 19, 24, 25, 25.4 and 26 mg/kg (JMPR 818 (1991)), 16 mg/kg (EHC 63 (1986)) for rats, and 4 of 31 values correspond to Category 1 and 27 of 31 values correspond to Category 2. The substance was classified into Category 2 since 27 values are in this category.
1 Acute toxicity (Dermal) Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
LD50 values are 155, 170, 220 and 220 mg/kg (ACGIH (2002)), 90, 225, 2500 and 5000 mg/kg (JMPR 818 (1991))) for rats, three values correspond to Category 2, three values correspond to Category 3 and two values correspond to "Not classified". The numbers of values corresponding to Category 2 and Category 3 are the same, the category with higher hazard was adopted and the substance was classified into Category 2.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on LC50 (4h) values of 0.107 mg/L, 0.155 mg/L (PATTY (5th, 2001)), 0.132 mg/L, 0.155 mg/L (JMPR 818 (1991)), 0.132 mg/L and 0.152 mg/L (ACGIH (2002)) for rats, the substance was classified into Category 2. The melting point of the substance is 72 - 73 degC (Merck (14th, 2006)). Since the substance was a solid at room temperature, the test was considered to be conducted for dusts.
2 Skin corrosion/irritation Not classified - - - - Based on results of not irritating in two rabbit tests (ACGIH (2002), JMPR 818 (1991)), the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on reports of "Caused no significant reaction" (JMPR 818 (1991) and "slightly irritating" (IUCLID (2000)) in rabbit tests, the substance was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
In 2 guinea pig skin sensitizing tests (maximization test and Buehler test), positive rates were 95% and approximately 50% (JMPR 818 (1991)), respectively. Based on positive results in both tests, the substance was classified into Category 1. As relevant information, the substance was classified into T; R43 in EU classification.
5 Germ cell mutagenicity Not classified - - - - Based on negative results in mouse dominant lethal tests by intraperitoneal (JMPR 255 (1973)) or oral administration (JMPR 818 (1991)) (in vivo heritable germ cell mutagenicity test) and a mouse bone marrow micronucleus test by intraperitoneal administration (in vivo somatic cell mutagenicity test) (ACGIH (2002)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of a negative Ames test (ACGIH (2002)), a positive CHO cell chromosomal aberration test (JMPR 818 (1991)) and a negative SCE assay (JMPR 818 (1991)).
6 Carcinogenicity Not classified - - - - Based on the classification of "A4" in ACGIH (ACGIH (2002)), the substance was classified as "Not classified". In carcinogenicity tests by oral administration to Osborne-Mendel rats and B6C3F1 mice for 80-weeks, neoplasms of the thyroid and pancreatic islets suggested, but did not provide sufficient evidence for carcinogenicity in male rats. No evidence for carcinogenicity was observed in female rats or in mice of either sex (NTP TR 69 (1978)).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In a developmental toxicity test in rabbits by oral administration during organogenesis period, a significant increase in pre-implantation loss, an increase in post implantation loss, and a significant decrease in live fetuses/doe were observed at doses in which tremors, ataxia and decreased cholinesterase activity were observed in maternal animals (ACGIH (2002)). Based on the data, the substance was classified into Category 2. In a two-generation reproduction test, a reduction in pup viability occurred at doses in which general toxicity such as increased dam mortality and decreased body weight was manifested (ACGIH (2002)).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
A case report reported symptoms of organophosphate poisoning in a human who spilled azinphos-methyl concentrate on his hands. He experienced visual disturbances, headache, tightness in the chest, and abdominal cramps (ACGIH (2002)). In a rat oral test, cholinesterase activity was inhibited and neurobehavioral effect was enhanced at dose levels of 3 - 6 mg/kg and higher. High mortality was noted at dose levels of 6 - 12 mg/kg (ACGIH (2002)). Based on the data, the substance was classified into Category 1 (nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In rats exposed by gavage for 13 - 16 weeks, cholinergic reactions or symptoms including salivation, lacrimation, muscle tremor and fasciculationa, a clear inhibition of erythrocyte and brain cholinesterase activities. Deaths were observed at dose levels of 3 - 6 mg/kg/kg and higher (PATTY (5th, 2001), ACGIH (2002), JMPR 111 (1968)). Several tests have indicated that orchard sprayers using azinphos-methyl showed a reduction in blood cholinesterase activity due primarily to dermal exposure (ACGIH (2002)). Based on the results in the rat oral test that cholinergic symptoms and cholinesterase activity inhibition accompanied by deaths were observed at dose levels within the guidance value range for Category 1 and several reports of reduction in blood cholinesterase activity by exposure during work in orchards, the substance was classified into Category 1 (nervous system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1 from its 96h-LC50 = 0.00029 mg/L for Crustacea (Mysid shrimp) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (BIOWIN).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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