Chemical Name:Camphor
CAS:76-22-2
ID: | 21B3039 |
Classifier: | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
Year Classified: | FY2009 |
Reference Manual: | GHS Classification Guidance by the Japanese Government (March, 2009) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
7 | Flammable solids | Category 2 | Warning | H228: Flammable solids |
P370+P378: In case of fire: Use ... for extinction. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
The substance is classified into Division 4.1, PG III in UNRTDG (UN2717). | |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified | - | - | - | - | Auto-ignition point is 460 degC (Hommel (1996)) exceeding 70 degC. |
11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Classified into Not classified since the substance is classified into Division 4.1, PG III, but not into upper Division 4.2 in UNRTDG. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable | - | - | - | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon. |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible | - | - | - | - | Classification not possible due to lack of data. As relevant information, a LD50 value is 1310 mg/kg for mice (HSDB (2005)). |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | Classification not possible due to lack of data. As relevant information, a LC50 value is 0.5 mg/L for rats (exposure period is unknown) (RTECS (2008)). Since the saturated vapour pressure concentration was 5.3 mg/L, it is considered that the test was conducted for vapour. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available. |
2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Although there is a report that application to the skin of volunteers as a 20% solution in alcohol produced sensations of irritation and pain (HSDB (2005)), classification was not possible due to lack of sufficient data. |
3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
There is a report that camphor may be somewhat irritating to the eyes, but no serious injuries have been reported (ACGIH (2001), PIMs (1988)) and the substance is classified as "Eye irr" by ACGIH (ACGIH-TLV (2005)). Based on these data, the substance was classified into Category 2B. |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
4 | Skin sensitization | Classification not possible | - | - | - | - | With chronic dermal exposure to the substance, contact dermatitis can occur as well as allergic responses (HSDB (2005)). Classification was not possible due to lack of other sufficient data. |
5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on a negative result in a mouse bone marrow micronucleus test by 90-day subcutaneous injection (in vivo somatic cell mutagenicity test) (NTP DB (access on Apr. 2009)), the substance was classified as "Not classified". As relevant information, there are reports of a positive sister chromatid exchange test by intraperitoneal administration (in vivo genotoxicity test) (HSDB (2005)) and a negative Ames test (in vitro mutagenicity test) (HSDB (2005)). |
6 | Carcinogenicity | Not classified | - | - | - | - | Based on the classification of "A4" in ACGIH (ACGIH-TLV (2005)), the substance was classified as "Not classified". |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | Although there is a report that camphor was used to induce abortions and it was implicated in fetal and neonatal death (PIMs: Camphor (PIM 095)), the details are unknown. It was also reported that the substance elicited no evidence of teratogenicity when administered orally during organogenesis period to pregnant rats or rabbits (HSDB (2005)). Since there were no data for effects on parental sexual function and fertility in the rat and rabbit tests, classification was not possible due to lack of sufficient data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system) | Danger | H370: Causes damage to organs (central nervous system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
There are numerous reports of cases describing serious symptoms which resulted in death or hospitalization after camphor ingestion (PIMs (1988), HSDB (2005)). Characteristic symptoms include nausea, convulsions, coma, seizures or grand-mal seizures, status epilepticus, and visual disturbances. In some cases, restlessness, confusion or delirium can occur (HSDB (2005)). Since the substance is reported to induce CNS stimulation and excitation of the cerebrum (PIMs (1988)), these symptoms are considered to be results from the CNS stimulation. The substance was classified into Category 1 (central nervous system). Although there is a report that renal damage may occur after intake of relatively small amounts (PIMs (1988)), the data were not used as the basis of classification since the detailed data are not available from case reports or animal tests. | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system, liver) | Danger | H372: Cause damage to organs through prolonged or repeated exposure (nervous system, liver) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
An illness resembling Reye's syndrome with coma and hepatomegaly was reported in a child who had been chronically administered the substance (PIMs (1988), HSDB (2005)). In a woman who regularly ingested the substance, hepatomegaly was found, with granulomas, necrosis and eosinophils apparent on biopsy (HSDB (2005)). In addition, headache, dyspnea, coma were reported as symptoms caused by occupational exposure (ACGIH (2001)). Based on the report of resembling Reye's syndrome and coma, and the findings of hepatomegaly, granulomas, necrosis and eosinophils on biopsy, the substance was classified into Category 1 (nervous system, liver). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Classified into Category 3 from its 96h-LC50 = 35 mg/L for fish (Zebrafish) (HSDB, 2005). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified | - | - | - | - | Classified into Not classified since it is rapidly degradable (BOD degradation rate: 94% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1994)) and low bioaccumulative potential is estimated (log Kow = 2.36 (PHYSPROP Database, 2009)). |
12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |