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Hazard class
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Classification
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Symbol
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Signal word
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Hazard statement
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Precautionary statement
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Rationale for the classification
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1
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Acute toxicity （Oral）
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Not classified
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-
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-
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-
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-
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Based on a LD50 value of >10,000 mg/kg for rats (Test Data for Supporting Registration of Pesticides, Japan Society For Occupational Health (JSOH): Recommendations for allowable concentrations (2008)), the substance was classified into "Not classified".
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1
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Acute toxicity （Dermal）
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Not classified
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-
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-
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-
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-
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Based on a LD50 value of >10,000 mg/kg for rats (Test Data for Supporting Registration of Pesticides, Japan Society For Occupational Health (JSOH): Recommendations for allowable concentrations (2008)), the substance was classified as "Not classified".
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1
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Acute toxicity （Inhalation: Gases）
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Not applicable
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-
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-
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-
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-
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Solid (GHS definition)
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1
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Acute toxicity （Inhalation: Vapours）
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Classification not possible
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-
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-
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-
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-
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No data available.
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1
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Acute toxicity （Inhalation: Dusts and mists）
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Classification not possible
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-
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-
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-
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-
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Although LC50 (4h) values were >4.1 mg/L (Test Data for Supporting Registration of Pesticides) and >3.94 mg/L (20% wettable preparation) for rats (Japan Society For Occupational Health (JSOH): Recommendations for allowable concentrations (2008)), classification was not possible since determination of the category was impossible. Since the test concentrations are higher than saturated vapour pressure concentration (3.3E-7 mg/L), the test was considered to be conducted for dusts.
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2
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Skin corrosion/irritation
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Not classified
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-
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-
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-
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-
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Since the substance was not irritating to the skin in a rabbit skin irritation test (GLP) (Test Data for Supporting Registration of Pesticides, Japan Society For Occupational Health (JSOH) Recommendations for allowable concentrations (2008)), the substance was classified as "Not classified".
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3
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Serious eye damage/eye irritation
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Not classified
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-
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-
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-
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-
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Since in an eye primary irritation test (Draize evaluation criteria) with rabbits, conjunctivae redness (score 1) was seen at 1 and 24-hour and resolved by 48-hour after application (Test Data for Supporting Registration of Pesticides, Pesticide safety information (Japan Crop Protection Association) (List open for the public) (1990)), the substance was classified as "Not classified".
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4
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Respiratory sensitization
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Classification not possible
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-
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-
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-
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-
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No data available.
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4
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Skin sensitization
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Not classified
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-
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-
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-
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-
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Based on results of "not skin sensitizing" in 2 skin sensitizing tests with guinea pigs (maximization test and Buehler test (GLP)) where skin reaction was not observed (positive rate: 0%) (Test Data for Supporting Registration of Pesticides), the substance was classified as "Not classified".
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5
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Germ cell mutagenicity
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Not classified
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-
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-
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-
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-
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Based on a negative result in a mouse bone marrow micronucleus test by oral administration (in vivo somatic cell mutagenicity test) (Test Data for Supporting Registration of Pesticides), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of negative CHL cell chromosomal aberration and bacterial (Salmonella typhimurium) reverse mutation tests (Test Data for Supporting Registration of Pesticides, Pesticide safety information (Japan Crop Protection Association) (List open for the public) (1990)).
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6
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Carcinogenicity
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Classification not possible
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-
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-
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-
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-
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There are no classifications by other organizations for the substance. Although the substance was concluded to be non-carcinogenic in a 36-month feeding test in rats (Test Data for Supporting Registration of Pesticides), the result was obtained from a single species. Classification was not possible due to lack of sufficient data.
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7
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Reproductive toxicity
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Not classified
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-
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-
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-
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-
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In a three-generation reproduction test in rats, there were no effects on reproductive performance such as fertility index, gestation index or implantation, and no treatment-related morphological abnormalities of the internal organ or skeleton of fetuses were observed (Japan Society For Occupational Health (JSOH) Recommendations for allowable concentrations (2008)). In a developmental toxicity test by oral administration to rabbits during organogenesis period, there were no effects on fertility index or implantation, and no teratogenic effects such as treatment-related morphological abnormalities of the internal organ or skeleton of fetuses (Japan Society For Occupational Health (JSOH) Recommendations for allowable concentrations). Since no parental fertility toxicity and no fetal developmental toxicity were observed, the substance was classified as "Not classified".
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8
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Specific target organ toxicity - Single exposure
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Classification not possible
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-
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-
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-
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-
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By oral administration, toxic symptoms were not observed at 10,000 mg/kg in rats or mice (Test Data for Supporting Registration of Pesticides). In addition, by dermal administration, no abnormality was noted in rats at 10,000 mg/kg (Test Data for Supporting Registration of Pesticides). Based on these data, the substance corresponds to "Not classified" with oral and dermal routes. By inhalation exposure (dust), increased nasal discharge and urinary incontinence were observed but no severe toxic effects were noted in rats at 4.1 mg/L for 4-hour (Test Data for Supporting Registration of Pesticides). However, since this test was only conducted at dose levels within the guidance value range, there is no data available for the effects at dose levels exceeding guidance value range. Classification was not possible due to lack of data with inhalation exposure routes.
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9
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Specific target organ toxicity - Repeated exposure
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Classification not possible
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-
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-
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-
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-
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Maximum non-effect levels (no observed adverse effect levels) obtained from oral administration tests are as follows: (a) rat oral (in diet) tests: 500 mg/kg day (Japan Society For Occupational Health (JSOH) Recommendations for allowable concentrations (2008)) and 2500 mg/kg/day (Pesticide safety information (Japan Crop Protection Association) (List open for the public) (1990)) by 3-month exposure; 363 - 809 mg/kg/day by 90-day exposure (Test Data for Supporting Registration of Pesticides); and 86 - 106 mg/kg/day by 36-month exposure (Japan Society For Occupational Health (JSOH) Recommendations for allowable concentrations (2008)); (b) mouse feeding tests: 7500 mg/kg/day by 3-month exposure (Pesticide safety information (Japan Crop Protection Association) (List open for the public) (1990)); (c) dog oral (capsule) test: 1000 mg/kg/day by 90-day exposure (Test Data for Supporting Registration of Pesticides) and 100 mg/kg/day by 53-week exposure (Test Data for Supporting Registration of Pesticides). Since all rat and mouse values exceed the upper limit (100 mg/kg/day) of the guidance value range for Category 2, the substance corresponds to "Not classified" with the oral route. However, classification was not possible due to lack of data with other exposure routes.
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10
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Aspiration hazard
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Classification not possible
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-
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-
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-
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-
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No data available.
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