GHS Classification Result (Revision of the past classification result)

Chemical Name:Ethyl methanesulfonate
CAS:62-50-0

Result:
ID: 21B3059
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Classification not possible - - - - Classification is not possible. Data are available that flash point is 100 degC (Gangolli vol. 4 (2nd, 1999), but the test method is unknown.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Classification not possible - - - - Classification is not possible since the substance contains oxygens and some of them are chemically bonded to atoms other than carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on a LD50 value of 470 mg/kg for mice (HSDB (2008)), the substance was classified into Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
There are positive results from in vivo somatic cell mutagenicity tests including bone marrow or peripheral blood micronucleus tests by oral gavage to mice (NTP DB (2004)), bone marrow chromosomal aberration test by intraperitoneal injection to mice (NTP DB (1983)) and erythrocyte micronucleus test by oral gavage and intraperitoneal injection to 2 mouse strains (HSDB (2000)). In addition, there is a report that the frequency of dominant lethal mutations increases with higher dose levels in mice (in vivo heritable germ cell mutagenicity test) (HSDB (2000)). Based on these results, the substance was classified into Category 1B. As relevant information, from in vitro mutagenicity tests, there are reports of a positive Ames test and a positive CHO cell chromosomal aberration test (NTP DB (1982, 1987)).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the classification of "Group 2B" in IARC (IARC suppl. 7 (1987)), the substance was classified into Category 2. As relevant information, the substance is classified into "R" in NTP (NTP RoC (11th, 1983)). The substance is reported to be carcinogenic in mice and rats and produce mainly lung and kidney tumours following subcutaneous or intraperitoneal injections (IARC 7 (1974)).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In a test where male rats administered by gavage for 5 days and mated to untreated females, effects on male fertility index and reduction in number of implants are reported (RTECS (2008): TXAPA9 Toxicology and Applied Pharmacology. 70 (1983)). Information on resorbed implants, fetal death and growth restriction are reported separately (RTECS (2008): JTSCDR Journal of Toxicological Sciences. 25 (2000)). In a similar test in mice, effects on male fertility index and death of offspring (RTECS (2008): JACTDZ Journal of the American College of Toxicology. 2 (2) (1983)) were reported. In addition, there are report that intraperitoneal injection to rats caused defect of limb and head (Birth Defects (3rd, 2000)) and that the substance produced subfertility and larger doses caused complete sterility in mice (IARC vol. 7 (1974)). It was also reported that intraperitoneal injection to pregnant mice induced high frequencies of midgestation and late fetal deaths, and of malformations among some of the surviving fetuses (HSDB (2008)). The data for oral route are on the document in List 3 and the details are unknown, and other data are results by intraperitoneal injection. Based upon the available information, the substance was classified into Category 2 since there is insufficient evidence to classify it in Category 1B.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Classification not possible due to lack of data.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - Classification not possible due to lack of data.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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