GHS Classification Result （Revision of the past classification result）

Chemical Name：Rosin
CAS：8050-09-7

Result：
ID: 21B3063
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available. (70 - 130 degC (IUCLID, 2000))
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on LD50 values of 7600, 8400 and ca. 7600 mg/kg for rats (IUCLID (2000)), the substance was classified into "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Based on LD50 values of >2500 mg/kg for rabbits and 2500 mg/kg for rats (IUCLID (2000)), the substance was classified as "Not classified" in JIS Classification.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on a LC50 (6h) value of approximately 1.5 mg/L (4-hour equivalence: approximately 2.3 mg/L) for rats (IUCLID (2000)), the substance was classified into Category 4. No data of the vapour pressure for this substance is available. However, since the substance was a solid with a vapour pressure of <0.1 hPa (IUCLID (2000)), the test was considered to be conducted for dusts.
2 Skin corrosion/irritation Not classified - - - - Based on a report of slightly irritating in rat tests (IUCLID (2000)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 3 in GHS classification).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on a report of slightly irritating in a rat test (IUCLID (2000)), the substance was classified into Category 2B.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		There are a number of case reports of asthma or asthma-like symptoms in workers handling pine resin, solderflux and resin acid which contained this substance (ACGIH (7th, 2001), DFGOT vol. 11 (1998)). Cases of workers complained of respiratory symptoms (ACGIH (7th, 2001)), decrease in expiratory flow, bronchitis, persistent symptoms and severe attacks of asthma related to their work (ACGIH (7th, 2001)) are also reported, and the incidence and severity of the symptoms are suggested to be related to exposure level (ACGIH (7th, 2001), DFGOT vol. 11 (1998)). In addition to these evidences, the substance is classified into Category 1 for respiratory tract sensitizer in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations (2008)). The substance was classified into Category 1.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		There is a report of positive results in a guinea pig maximization test (IUCLID (2000)). There are case reports of allergic contact dermatitis in humans attributed to the substance or products containing the substance (ACGIH (7th, 2001), DFGOT vol. 11 (1998)). The substance is classified into R43 in EU classification (EU-Annex I (access on May 2009)), therefore, the substance was classified into Category 1.
5 Germ cell mutagenicity Not classified - - - - Based on a negative result in a bone marrow micronucleus test by oral administration to mice (in vivo somatic cell mutagenicity test) (Kurita T.; Study results for preparation of standards and criteria for food additives in 1997, The Institute of Environmental Toxicology), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of a negative bacterial reverse mutation test and a negative mammalian cell chromosomal aberration test (Research on the revision of the safety of the existing additive (Ministry of Health, Labour and Welfare) (2004)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although changes were noted in some hematological or blood biochemical parameters in a 90-day feeding test in rats, histopathological findings were not observed and significant toxic effects were not found at a feeding concentration of 0.5% (approximately 239 - 282 mg/kg/day) (Evaluation of Safety of Existing Food Additives (2004); Watanabe H.; Study results for preparation of standards and criteria for food additives in 1998, Hiroshima University). The substance corresponds to "Not classified" with the oral route. However, classification was not possible due to lack of data with other exposure routes.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 2 from its 48h-EC50 = 4.5 mg/L for Crustacea (Daphnia magna) (IUCLID, 2000).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (BOD degradation rate: 36 - 46%) (IUCLID, 2000)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information