GHS Classification Result （Revision of the past classification result）

Chemical Name：Sodium azide
CAS：26628-22-8

Result：
ID: 21B3070
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - The substance is not classified into Class 1 in UNRTDG though it contains chemical groups (azido group) associated with explosive properties present in the molecules. The substance does not fall into "Explosives" also in the Subsidiary risk.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Classification is not possible since the description in literatures is split over flammability such as "Flammable solids" (Hommel (1996)), "Not flammable" (Weiss (2nd. 1985), HSFS (2008)), "Not considered flammable unless heated above 300 degC" (HSDB (2009)) (SITTIG (5th, 2008)). The substance is not classified into Division 4.1 (Flammable solids, self-reactive substances and soid desensitized explosives) in UNRTDG (UN1687).
8 Self-reactive substances and mixtures Type G - - - - Classified into Type G since the substance is classified into Division 6.1 (Toxic substances), but not into Division 4.1 (Flammable solids) in UNRTDG though there are chemical groups (azido group) associated with explosive properties present in the molecules. The substance had been practically used as the propellant to blow air bags up at the auto collision (ACGIH (2001)).
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Classified into Not classified since the substance does not burn at room temperature (Patty (5th, 2001)).
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - The substance is judged to be stable against water from water solubility 41.7 g/100 mL (17 degC) (ICSC (J) (1997)).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Inorganic compounds containing no oxygen and halogen atoms
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available. Information is available that the substance is strongly corrosive to aluminum (HSDB (2009)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a LD50 value of 45 mg/kg for rats (DFGOT vol. 20 (2003)), the substance was classified into Category 2.
1 Acute toxicity （Dermal） Category 1 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a LD50 value of 20 mg/kg for rabbits (ACGIH (2001)), the substance was classified into Category 1.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data. Although a LC50 value was 37 mg/m3 for rats (RTECS (2008)), the exposure period was not clear.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a report that application to rabbit skin caused corrosion after 4-hour and 3 of 6 rabbits died (DFGOT vol. 20 (2003)), the substance was classified into Category 1.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Since the substance is classified into Category 1 for skin corrosion, Category 1 was also applied for the eyes.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of a positive bacteria reverse mutation test (ACGIH (2001), negative chromosomal aberration tests using human lymphocytes and Chinese hamster ovary cells, and a negative gene mutation test using mouse lymphoma cells (DFGOT vol. 20 (2003)). The strong mutagenic effects of the substance are considered to be specific to bacteria (DFGOT vol. 20 (2003)).
6 Carcinogenicity Not classified - - - - Based on the classification of "A4" in ACGIH (ACGIH-TLV (2005)), the substance was classified as "Not classified". In a 2-year oral test in rats, body weight gain was decreased dose-dependently and viability was decreased in the high dose group. There was no evidence of carcinogenicity (NTP TR389 (1991)).
7 Reproductive toxicity Classification not possible - - - - In a test where hamsters were given infusions of the substance from subcutaneously implanted osmotic mini-pumps between days 7 and 9 of gestation, 2/15 dams died. The incidence of early resorptions was significantly higher and encephalocele developed in foetuses (DFGOT vol. 20 (2003)). However, since the results were inadequately documented and the exposure route employed is unconventional, it is not possible to assess prenatal toxicity on the basis of this test (DFGOT vol. 20 (2003)). Classification was not possible.
8 Specific target organ toxicity - Single exposure Category 1 (cardiovascular system, lung, central nervous system, systemic toxicity) Danger H370: Causes damage to organs (cardiovascular system, lung, central nervous system, systemic toxicity) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The following case reports are available: Accidental poisoning of five laboratory technicians due to ingestion caused pounding of the heart, faintness and myocardial ischemia (NTP TR389 (1991)); Altered mental status, pronounced acidosis, cardiac arrhythmia, decreased cardiac output, and hypotension preceded the death of a chemist who ingested 10 to 20 g of the substance (NTP TR389 (1991)); and A laboratory technician who accidentally ingested a very small amount of the substance was observed to have tachycardia, hyperventilation, and hypotension (HSDB (2009)). In addition, there is a report that the target organ of the substance is the cardiovascular system; it causes dilation of peripheral blood vessels which results in very marked reductions in blood pressure (DFGOT vol. 20 (2003)). Based on the data, the substance was classified into Category 1 (cardiovascular system). In above cases, dizziness, lipothymia, altered mental status, noncardiac pulmonary edema and metabolic acidosis were also observed. In a human suicide case by the ingestion of several grams of the substance, pulmonary edema and brain edema were the finding at autopsy (ACGIH (2001)). Based on the data, the substance was classified into Category 1 (lung, central nervous system, systemic toxicity). In rats, decreased heart rate and generalized convulsions were observed following oral administration (DFGOT vol. 20 (2003)). In rabbits, an oral dose caused reduction in blood pressure and cardiac irregularities (PATTY (5th, 2001)).
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, cardiovascular system), Category 2 (lung) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, cardiovascular system)
H373: May cause damage to organs through prolonged or repeated exposure (lung) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In a 13-week repeated oral test with rats, clinical findings at the highest dose (20 mg/kg/day) included lethargy, labored breathing and death. Histopathological lesions were necrosis of the cerebrum and thalamus (NTP TR389 (1991)). In a 2-year repeated oral test with rats, reduced survival was observed at the highest dose (10 mg/kg/day), which was attributed to brain necrosis and cardiovascular collapse induced by exposure to the substance (NTP TR389 (1991)). Based on the data, the substance was classified into Category 1 (central nervous system, cardiovascular system). In addition, in the reported 13-week oral test with rats, congestion, hemorrhage, and edema in the lung were observed in rats receiving 20 mg/kg. Based on this data, the substance was also classified into Category 2 (lung). In a repeated oral dose test in dogs (1 - 10 mg/kg/day), ataxia and histomorphological changes in the cerebrum were observed (HSDB (2009)). In humans, serious adverse effects following exposure are not reported.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 from its 96h-ErC50 = 348 microg/L for algae (Pseudokirchneriella subcapitata) (AQUIRE, 2010).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (Degradation rate by direct measurement (HPLC): 1% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2000)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information