GHS Classification Result （Revision of the past classification result）

Chemical Name：Adiponitrile
CAS：111-69-3

Result：
ID: 21B3071
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point 159 degC (closed-cup) (ICSC (1995)), 163 degC (Hommel (1996)) are 110 degC. Information is available that flash point of industrial product is 93 degC (open-cup) (Hommel (1996)).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 550 degC (ICSC (1995), NFPA (13th, 2006), HSDB (2009)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		LD50 values are 138 mg/kg, 300 mg/kg (SIDS (access on May 2009)), 155 mg/kg (Initial Environmental Risk Assessment of Chemicals (Ministry of Environment) vol. 3 (2004)) and 500 mg/kg (ACGIH (2001))) for rats. Since three values correspond to Category 3, the substance was classified into Category 3.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		LD50 values are 800 mg/kg (ACGIH (2001)) and >2000 mg/kg (SIDS (access on May 2009)) for rabbits. The category with higher hazard was adopted and the substance was classified into Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on LC50 values of 1.71 mg/L/4h (SIDS (access on May 2009), Initial Environmental Risk Assessment of Chemicals (Ministry of Environment) vol. 3 (2004)) and 3 mg/L/4h (ACGIH (2001)) for rats, the substance was classified into Category 4. The tests were conducted at concentrations higher than saturated vapour pressure concentration.
2 Skin corrosion/irritation Not classified - - - - Based on a result of "no irritation" in a rabbit skin irritation test (ACGIH (2001)), the substance was classified as "Not classified". As relevant information, seven cases of skin exposure were reviewed. Six of the cases resulted in skin irritation and inflammation, 5 to 15 minutes following exposure. In the seventh case, a worker suffered extensive destruction of the skin on one foot after his shoe was drenched with the substance. He was incapacitated for 117 days (ACGIH (2001)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on a result of "slightly irritating" during 8-day observation period in a rabbit test (SIDS (access on May 2009), IUCLID (2000)), the substance was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - Based on negative results in a guinea pig skin sensitizing test (SIDS (access on May 2009), ACGIH (2001), IUCLID (2000)), the substance was classified as "Not classified".
5 Germ cell mutagenicity Not classified - - - - Based on a negative result in a rat bone marrow chromosomal aberration test (in vivo somatic cell mutagenicity test) (SIDS (access on May. 2009), IUCLID (2000)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of a negative Ames test (ACGIH (2001), SIDS (access on May. 2009)), a negative mouse lymphoma test (SIDS (access on May. 2009)) and a negative rat hepatic cell unscheduled DNA synthesis test (SIDS (access on May. 2009)).
6 Carcinogenicity Not classified - - - - Based on the classifications of "D" (not classifiable as to human carcinogenicity) in EPA (1991), the substance was classified as "Not classified". In a 2-year drinking test in rats (ACGIH (2001)), there were no increases in tumor incidence.
7 Reproductive toxicity Not classified - - - - In a 3-generation reproductive test in rats administered in drinking water, no effect upon the indices of fertility, gestation or viability was observed (ACGIH (2001)). In inhalation exposure tests, female rats exposed for 22 days were mated to unexposed males and male rats exposed for 74 days were mated to unexposed females. In both cases, sexual function and reproductive performance were unaffected (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004)). In a developmental toxicity test in rats by gavage on gestation days 6 - 19, 1 and 2 dams died in the middle and high dose groups, respectively. No adverse effects were observed on fetal development including teratogenicity (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004)). Based on the data, the substance was classified as "Not classified" since there were no adverse effects on parental sexual function and fertility and fetal development.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is a case report of an accidental swallowing of a few mL of the substance in which vomiting, chest tightness, weakness, dizziness and cyanosis appeared within 20 minutes. Following the initial symptoms, tachycardia, tachypnea, decreased blood pressure, mydriasis, tonic/clonic contraction of limb and facial muscles and confusion were also observed (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004), PATTY (5th, 2001)). Most victims of acute poisoning either die acutely or recover fully. In rare incidents, cases of neurological sequelae such as personality changes, memory deficits, and extrapyramidal (Parkinsonian-like) syndromes were reported (HSDS (2009)). Based on the data, the substance was classified into Category 1 (nervous system). In animal inhalation tests, increased respiration, sluggish movement and slight cyanosis were seen in mice (ACGIH (2001)), and convulsion and lethargy were seen in rats (Hazard Data Book for Chemical Substance (CERI) 2001-17 (2002)).
9 Specific target organ toxicity - Repeated exposure Category 2 (blood) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In a 4-week inhalation exposure test in rats, more than half of the animals died at 493 mg/m3, and decreases in mean cell hemoglobin concentration (MCHC), hemoglobin concentration and hematocrit, hemosiderin pigmentation and extramedullary hematopoiesis in the spleen were observed at 114 mg/m3 (90-day equivalent: 0.035 mg/L) and higher levels (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004)). Additionally, in a 13-week inhalation exposure test, anemia was observed at 0.99 mg/L (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004)), and in a dermal test with guinea pigs, hyperchromic anemia was observed after 3 to 16 doses (ACGIH (2001)). Nylon workers were reported to exhibit a tendency to hyperchromic anemia of the hemolytic type, slight leukopenia, and sometimes lymphomonocytosis following exposure to the substance. However, this human exposure was to a mixture of substances and there is not enough data presented to reach any clear-cut conclusion as to the relationship with the substance (ACGIH (2001)). Insufficient data was obtained for humans from these reports. Based on the animal data, the substance was classified into Category 2 (blood system). In a 2-year drinking water test in rats, degeneration in the adrenal gland was noted in the males (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004)), however, this data was not used as the basis of classification since it is from a 2-year test and a similar finding was not observed in a 13-week test.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Classified into Not classified from its 96h-LC50 = 670 mg/L for fish (Rainbow trout) (SIDS, 1998), 24h-EC50 = 445 mg/L for Crustacea (Daphnia magna) (SIDS, 1998) and 96h-EC50 >100 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 1998).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified into Not classified since its acute toxicity is Not classified and it is not non-water soluble (Water solubility = 80000 mg/L (PHYSPROP Database, 2009).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information