GHS Classification Result （Revision of the past classification result）

Chemical Name：Acetoxyphenylmercury (II)
CAS：62-38-4

Result：
ID: 21B3079
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - The substance is slightly soluble in water, heavier than water and sinks in water (Hommel (1996)). Water solubility is 0.44 g/100 mL (20 degC) (ICSC (J) (2000)).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - Classification is not possible since no data are available though the substance is an organic compound containing oxygen which is chemically bonded to atoms except carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available. Information is available that aluminum is not suitable for containers since it is subjected to a corrosive action (Hommel (1996)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a LD50 value of 22 mg/kg (HSDB (2005)) for rats, the substance was classified into Category 2.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a patch test in which a 0.1% solution of the substance was applied to humans for 24-hour, a vesicular rash (grade of 4+) was observed, and this substance was judged to be a primary irritant (RTECS (2008): Archives of Dermatology 106, 129 (1972)). Redness, pain, blurred vision and severe deep burns are reported following exposure to this substance (ICSC (J) (2005)). In EU classification, the substance is classified into R34 (EU-Annex I (access on May 2009)). Based on the data, the substance was classified into Category 1.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		As information in documents in List 3, redness, pain, blurred vision and severe deep burns are reported following exposure to the substance (ICSC (J) (2005)). In a rabbit standard Draize test, "severe" result is reported (RTECS (2008)). The substance is classified into Category 1 and skin corrosive substance. Based on these data, the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		In a guinea pig Buhler test, positive results were obtained in 14/18 (77.8%) animals (DFGOT vol. 15 (2001)). Based on the data, the substance was classified into Category 1. In humans, patch tests were carried out with a 0.01% solution of the substance and positive results were obtained in 29 (1.4%) of the 2030 patients tested (21 of these were only weakly positive) (DFGOT vol. 15 (2001)). In other patch tests with 0.01% and 0.05% solutions, positive rates were 1.4% and 5.8%, respectively (DFGOT vol. 15 (2001)). The substance is classified as Sh in DFG.
5 Germ cell mutagenicity Classification not possible - - - - Although there is a report that an increased incidence of SCE was found in the lymphocytes of 38 Argentinean children who were exposed to phenylmercuric acetate used as a disinfectant in nappies, but 9 months after the end of exposure, the incidence of SCE was no longer increased (in vivo somatic cell mutagenicity) (DFGOT vol. 15 (2001)), the details are unknown. Classification was not possible due to lack of sufficient data from in vivo mutagenicity tests. As relevant information, from in vitro mutagenicity tests, there is a report of a negative Ames test (NTP DB (access on May 2009)).
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data. In a 103-week oral (in drinking water) test in male rats, the incidence of tumors in the high dose group was significantly increased in comparison to the control group. The increase in number of incidences were a result of an increase in the incidence of renal cell adenomas (DFGOT vol. 15 (2001)).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is reported that acetoxyphenylmercury is a strong teratogen for more than one animal species as it induces disorder of the central nervous system and eye, and anury in mice, multiple malformation in rats and rabbits, and exencephaly in hamsters (Birth Defects (3rd, 2000)). When hamsters, rats and mice were administered by stomach tube from days 5 - 12 of gestation, embryotoxic effects induced were resorptions, dead fetuses, and retardation of development. Teratogenic effects were diminished cranial ossification, edemata of body, hematomas and open eyes (HSDB (2009)). Although there are reports of teratogenicity in more than one animal species, the data are in assessment documents in List 2, therefore the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - There is a report that a single dose exposure to rats caused hematological effects such as morphological alterations in erythrocytes and inhibited platelet factor (HSDB (2009)). However, since required information about test method and results are not reported, classification was not possible.
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney, nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (kidney, nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In a 2-year oral test in rats, nephropathy was observed at dietary phenylmercuric acetate concentrations of 0.042 mg/kg/day and higher. Renal lesions were observed at 0.21 mg/kg/day and higher concentrations in both sexes (IRIS (2002)). In rats given phenylmercuric acetate at concentrations of 0.71 - 7.1 mg/kg/day in drinking water for 2-year, pigment deposits were found in the renal cortex and the incidence and severity of age-related chronic nephrosis were increased. The authors suggested that the mechanism of the carcinogenicity could involve the effects of the substance (DFGOT vol. 15 (2001)). Since these renal lesions were noted at dose levels within the guidance value range for Category 1, the substance was classified into Category 1 (kidney). A 39-year-old farmer who had treated seeds with phenylmercuric acetate for 6 ? 7 seasons died within several months of developing severe neurological toxicity (ATSDR (1999)). A 39-year-old farmer exposed while dusting oat seeds with the substance, excreted large amounts of mercury in the urine, died of an apparently progressive neurologic disease resembling amylotrophic lateral sclerosis (HSDB (2009)). Based on these case reports of neuropathy where the involvement of the exposure is suggested, the substance was classified into Category 1 (nervous system). There is another exposure case report which describes a swollen mouth, reddened and tender gums, a thin blue line at the gums and carious teeth (ATSDR (1999)), however, these symptoms can not affect the alimentary system severely, therefore the data was not used as the basis of classification. As for effects on the respiratory system, there is a case report where dyspnea and respiratory depression were observed and an autopsy revealed purulent bronchopneumonia. However, it is unclear whether the respiratory effects were direct effects of the phenylmercuric acetate or secondary to the severe neurotoxicity also seen in this subject (ATSDR (1999)). Based on this uncertainty this respiratory system data was not used as the basis of classification.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 from its 96h-LC50 = 8.6 microg/L for fish (Rainbow trout) (AQUIRE, 2010).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 since its acute toxicity is Category 1 and the behavior in water and bioaccumulative property are unknown from which it is a metal compound.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information