GHS Classification Result （Revision of the past classification result）

Chemical Name：Ethylidene norbornene
CAS：16219-75-3

Result：
ID: 21B3084
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - Classification is not possible since no data are available though the substance contains chemical groups (unsaturated C-C bond) associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point 38 degC (open-cup) (ICSC (1999)) is >=23 degC and <=60 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - Classification is not possible since no data are available though there are chemical groups (unsaturated C-C bond) associated with explosive properties present in the molecules.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 272 degC (SIDS (2004)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on LD50 values of 2276 mg/kg (male), 5071 mg/kg (female) (SIDS (2002)), 2550 mg/kg (ACGIH (2001)), 3200 mg/kg and 2290 mg/kg (PATTY (5th, 2001) for rats, the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 in GHS classification).
1 Acute toxicity （Dermal） Not classified - - - - Based on LD50 values of 8253 mg/kg (ACGIH (2001)) and >7168 mg/kg (SIDS (2002)) for rabbits, the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on rat LC50 values of 2717 ppm/4h (male) and 3015 ppm/4h (female) (SIDS (2002)), the substance was classified into Category 4. Since saturated vapour pressure concentration of the substance is 5518 ppm, the test was considered to be conducted for vapour with almost no included mists and classification criteria for gas were adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - In a skin irritation test in rabbits by 4-hour application, there was mild to moderate erythema and edema, most marked at 1 - 2 days, thereafter slowly resolving and complete resolution by 14 days. Average score of more than 2.3 for erythema or edema was noted in less than 4 of 6 animals. The substance is a mild irritant (SIDS (2002)). Based on these data, the substance was classified as "Not classified" in JIS Classification (correspond to Category 3 in GHS classification).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		In a rabbit eye irritation test with this substance, there was slight conjunctival hyperemia, which began to resolve after 24-hour with all eyes normal by 7 days. Iritis and corneal injury were not noted (SIDS (2002)). The substance was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - Based on a negative result in a dominant lethal test by inhalation exposure to rats (in vivo heritable germ cell mutagenicity test) (SIDS (2002)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of a negative Ames test and a negative hamster cell chromosomal aberration test ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (2005), SIDS (2002)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		When the substance was administered orally for 45 days from 14 days before mating in male rats and from 14 days before mating to day 3 of lactation in female rats, two dams died and decreases in body weight gain and food consumption were observed at the high dose level (100 mg/kg). At this dose level, prolongation of the gestation period and decreases in the number of implantation and delivery indices were observed, and the total number of births, the number of live offspring at birth and the number of live offspring on day 4 of lactation were decreased ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (2005), SIDS (2002)). Based on the data, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (central nervous system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		In an oral acute toxicity test, rats showed sluggishness, lacrimation, kyphosis, unsteady gait followed by piloerection and intermittent tremors at a dose level of 2.0 mL/kg (1800 mg/kg) and higher dose levels (SIDS (2009)). In an inhalation acute toxicity test, rats showed hindlimb paralysis, absent surface righting and toe and tail pinch reflexes at dose levels of 10.8 - 16.9 mg/L (SIDS (2002)). Inhalation exposure to dogs caused tonic convulsions at dose levels of 10.7 - 15.9 mg/L (HSDB (2005)). At these concentrations within the guidance value range for Category 2, signs are predominantly those of a central excitatory nature, particularly tremors, and convulsions (SIDS (2002)). For humans, exposure to the substance can cause nausea, vomiting, headache, confusion and respiratory distress (PATTY (5th, 2001)). Based on the data, the substance was classified into Category 1 (central nervous system). Human volunteers noted irritation of eyes and nose following 30-min exposures. The vapour is irritating to the throat and will cause coughing or difficult breathing (PATTY (5th, 2001)). Based on the data, the substance was classified into Category 3 (respiratory tract irritation). There is a report that diarrhea, gastrointestinal hemorrhage and distension of the stomach were noted in a rabbit dermal test (HSDB (2005)). However, this data was not used as the basis of classification since the gastrointestinal hemorrhage is considered to appear at a very high dose only and similar results are not observed in other tests.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In inhalation tests, cell degeneration in the liver was observed in rats after a 88-day exposure of 237 ppm (1.165 mg/L). An increase in liver enzyme, bile duct proliferation and portal fibrosis were observed in dogs after 88-day exposure of 61 ppm (0.300 mg/L) (SIDS (2002)). In an oral preliminary reproductive toxicity test in rats, centrilobular hepatocyte hypertrophy and cellular vacuolization were noted at a dose level of 100 mg/kg/day (90-day equivalence: 50 mg/kg/day) and higher dose levels ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (2005)). Since the hepatotoxicity occurred at dose levels within the guidance value range for Category 2, the substance was classified into Category 2 (liver). Treatment-related effects were also observed in the kidney and thyroid (SIDS (2002)). However, these effects were not used as the basis of classification since the kidney effects are consistent with male-rat-specific alpha-2u-globulin nephropathy which is not relevant for humans and the thyroid effects are reversible following a 4-week recovery period and the toxicological significance of these effects are unclear.
10 Aspiration hazard Category 1 Danger H304: May be fatal if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on reports that "aspiration causes severe pneumonia" in humans (PATTY (5th, 2001)) and "If this liquid is swallowed, aspiration into the lung may result in chemical pneumonitis" (ICSC (J) (1999)), the substance was classified into Category 1.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 2 from its 48h-EC50 = 3.3 mg/L for Crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1998).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (BOD degradation rate: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1985)).
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information