GHS Classification Result (Revision of the past classification result)

Chemical Name:Cadmium chloride
CAS:10108-64-2

Result:
ID: 21B3100
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Not combustible (ICSC (2005))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - The substance is "Not combustible" (ICSC (2005)), and it does not spontaneously ignite on contact with room temperature air.
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC (2005))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - The substance is considered to be stable against water since data are available that water solubility is 140 g/100 mL (20 degC) (HSDB (2009)) through it contains metals (Cd).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - Classification is not possible since no data are available though the substance is inorganic compound containing chlorine.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on LD50 values of 107, 129, 225, 327 mg/kg (PATTY (5th, 2001) and 88 - 302 mg/kg (CaPSAR (1994)) for rats, the substance was classified into Category 3. There is a data of a LD50 value of 29 mg/kg for 2-week old rats (PATTY (5th, 2001).
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available. As relevant information, there is a report of "causes smarting of the skin and first degree burns on short exposure" for human effects (HSDB (2009)).
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - Based on a negative result in a guinea pig maximization test (DFGOT vol. 22 (2006)), the substance was classified as "Not classified".
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on (weakly) positive results from in vivo germ cell mutagenicity tests (oocyte and spermatocyte aneuploidy assay) and positive results from in vivo somatic cell mutagenicity tests (chromosomal aberration test, micronucleus test) (IARC 58 (1993)), the substance was classified into Category 1B. As relevant information, there are reports of a negative in vivo heritable mutagenicity tests (dominant lethal test, translocation test) (IARC 58 (1993)). From in vitro mutagenicity tests, there are reports of positive results in a majority of Ames tests, and positive results in a mouse lymphoma test, a chromosomal aberration test and a sister chromatid exchange test (IARC 58 (1993), NTP DB (access on May 2009)).
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since cadmium and cadmium compounds are classified into "Group 1" in IARC (IARC 58 (1993)), "K" in NTP (NTP Roc (11th, 2004)), and as "Category 1" in Japan Society For Occupational Health (JSOH), the substance was classified into Category 1A.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In an oral reproductive test in rats, there was no effect on male fertility but decreases in the mating index, implantation index and number of live fetuses were observed (IARC 58 (1993)). Since there was no information for the maternal general toxicity, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, liver, digestive system) Danger H370: Causes damage to organs (respiratory system, liver, digestive system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
For the substance there is a report of "liver damage" for humans (ATSDR (2008)). In rats, "pulmonary edema (0.005 mg/L/1h), pneumonitis (0.0065 mg/L/1h), alveolar pneumocyte type 1 cell damage and necrosis (0.006 mg/L/2h)" were noted after inhalation (dust) exposure (ATSDR (2008)) and "focal degeneration and necrosis of parenchymal cells in the liver (75 mg/kg)" were observed after oral administration (ATSDR (2008)). These effects were observed at dose levels within the guidance value range for Category 1. In addition, as acute effects of cadmium compounds to humans, "chemical pneumonitis and oedema after inhalation exposure, and rapid onset with severe nausea, vomiting, and abdominal pain after ingestion" are characteristic symptoms (EHC 134 (1992)). Based on the data, the substance was classified into Category 1 (respiratory system, liver, alimentary system).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, bone, liver, kidney, heart) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, bone, liver, kidney, heart) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
For the substance, in inhalation (dust) tests with rats, mice and hamsters, inflammatory and proliferative changes in the lungs were induced at an exposure concentration of 0.4 - 0.5 microg/L/4h (CaPSAR (1994)). In oral tests with rats, changes in calcium metabolism and osteomalacia (1 microg/kg/day for six months) (EHC 61 (1988), ATSDR (2008)), necrosis of central lobules in the liver and necrosis of proximal tubular epithelial cells (8.58 mg/kg/day for 12 weeks), anemia, osteomalacia (3.6 mg/kg/day for 120 days), and congestion and separation of muscle fibers in the heart (2.5 mg/kg/day for 7 weeks) were noted (ATSDR (2008)). Based on the data, target organs were considered to be lung, bone, liver, kidney and heart. The effects on animals were observed at dose levels within the guidance value range for Category 1. The substance was classified into Category 1 (respiratory system, bone, liver, kidney, heart).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1 from its 96h-LC50 = 0.00138 mg/L for Crustacea (Mysidacea) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1 since its acute toxicity is Category 1 and the behavior in water is unknown from which it is a metal compound.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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