GHS Classification Result （Revision of the past classification result）

Chemical Name：Cadmium oxide
CAS：1306-19-0

Result：
ID: 21B3103
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Not combustible (ICSC (2005))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Not combustible (ICSC (2005))
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC (2005))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - The substance is considered to be stable against water since data is available that it is insoluble in water through it contains metals (Cd) (ICSC (2005)).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - Classification is not possible since no data are available though the substance is inorganic compound containing oxygen.
15 Organic peroxides Not applicable - - - - Not organic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a LD50 value of 72 - 296 mg/kg for rats (CaPSAR (1994)), the substance was classified into Category 3.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a lethal dose of 0.012 mg/L (4-hour equivalence) for humans exposed cadmium oxide fumes (EHC 134 (1992)), the substance was classified into Category 1.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Since there are a number of case reports of skin irritation following exposure to high levels of cadmium oxide fumes (CaPSAR (1994)), the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Since there are a number of case reports of eye irritation following exposure to high levels of cadmium oxide fumes (CaPSAR (1994)), the substance was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there is a report of a negative result in an inhalation mouse bone marrow micronucleus test (NTP DE (access on June 2009), the exposure conditions for the substance are unknown. It cannot be excluded that the substance can exert genotoxic effects in consideration of a genotoxic potential reported with cadmium ion (water soluble cadmium compounds) (EU RAR 75 (2007). Based on the information, the substance was classified into Category 2. As relevant information, from in vitro mutagenicity tests, there are reports of negative Ames tests (IARC 58 (1993), NTP TOX39 (1995), NTP DB (access on June 2009)). There is a report that humans who had been exposed to cadmium (itai-itai patients) showed chromosomal aberrations in peripheral blood lymphocytes (IARC 58 (1993)). In addition, the substance is classified into R68 in EU classification.
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since cadmium and cadmium compounds are classified into "Group 1" in IARC (IARC 58 (1993)), "K" in NTP (NTP Roc (11th, 2004)), and into Category 1 in Japan Society For Occupational Health (JSOH), the substance was classified into Category 1A.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In an inhalation developmental toxicity test in mice, a lower pregnancy rate, increased total number of resorptions per litter and an increase in the incidence of reduced sternebral ossification were observed at doses that were parental general toxic (NTP TOX39 (1995)). Based on the data, the substance was classified into Category 2. As relevant information, lower offspring body weight was observed at dose levels that were not parental general toxic.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, digestive system) Danger H370: Causes damage to organs (respiratory system, digestive system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		For humans, a case of pneumonitis was reported for a man exposed to the substance for 3 days (ACGIH (7th, 2001)). Additionally, there is a report that 9 years after a single exposure to the substance, a worker continued to show signs of progressive pulmonary fibrosis and had no improvement in respiratory function (ATSDR (2008)). In dust inhalation tests with rats, exposures to 1 - 10 mg/m3 resulted in interstitial pneumonitis, alveolar epithelial hyperplasia, alveolitis with hemorrhage, and hyperplasia of fibroblasts (ATSDR (2008)). In addition, as acute effects of cadmium compounds to humans, "chemical pneumonitis and oedema after inhalation exposure, and rapid onset with severe nausea, vomiting, and abdominal pain after ingestion" are characteristic symptoms (EHC 134 (1992)). Based on the data, the substance was classified into Category 1 (respiratory system, alimentary system).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, kidney, bone, cardiovascular system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, kidney, bone, cardiovascular system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		There are reports of "in humans, long term inhalation of cadmium oxide fumes or dusts leads to reduced lung function and emphysema" and "a substantial body of information is available indicating that the lung, kidney and bone are the main target organs upon repeated exposure to cadmium oxide/cadmium metal in occupational settings (mainly by inhalation)" (SIDS (2004)). Additionally, it was reported that hypertension and abnormalities in the electrocardiogram were observed in workers at a battery factory exposed to cadmium oxide dust (EHC 134 (1992)). Based on the data, the substance was classified into Category 1 (respiratory system, kidney, bone, cardiovascular system). As relevant information, as chronic effects of cadmium compounds to humans, "renal dysfunction such as glomerular proteinuria, hypercalciuria, disturbances in rate of calcium to phosphate, hypophosphataemia, formation of renal stones, osteomalacia and osteoporosis" are characteristic (EHC 134 (1992)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 from its 72h-ErC50 = 79 microg/L (90 microg/L as cadmium oxide) for algae (Pseudokirchneriella subcapitata) (EU-RAR, 2003)
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 since its acute toxicity is Category 1 and the behavior in water is unknown from which it is a metal compound.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information