GHS Classification Result (Revision of the past classification result)

Chemical Name:Cadmium sulfide
CAS:1306-23-6

Result:
ID: 21B3104
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Classification is not possible since no data are available though the substance is combustible (ICSC (2007)).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - The substance is considered to be stable against water since data are available that it is insoluble in water through it contains metals (Cd) (ICSC (2007)).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Inorganic compounds containing no oxygen and halogen atoms
15 Organic peroxides Not applicable - - - - Not organic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on LD50 values of >5000 mg/kg (CaPSAR (1994)) and 7080 mg/kg (HSDB (2009)) for rats, the substance was classified into "Not classified". For mice, a LD50 value of 1166 mg/kg (EHC 134 (1992)) corresponds to Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available. As relevant information, there is a report that direct contact with a solution of this substance may produce erythema and pain in humans (HSDB (2009)).
3 Serious eye damage/eye irritation Classification not possible - - - - No data available. As relevant information, conjunctivitis, photophobia, lacrimation, and corneal opacity may be caused in humans following exposure to this substance (HSDB (2009)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
No data from in vivo mutagenicity tests are available. The substance is a water insoluble cadmium compound. However, it cannot be excluded that the substance can exert genotoxic effects in consideration of germ cell mutagenicity potential suggested with cadmium chloride, a representative water soluble cadmium compound. Therefore, the substance was classified into Category 2. As relevant information, from in vitro mutagenicity tests, there is a report of a positive chromosomal aberration test using human lymphocytes (IARC 58 (1993). Refer also to cadmium chloride (CAS: 10108-64-2).
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since cadmium and cadmium compounds are classified into "Group 1" in IARC (IARC 58 (1993)), "K" in NTP (NTP Roc (11th, 2004)), and into Category 1 in Japan Society For Occupational Health (JSOH), the substance was classified into Category 1A.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
There is no available data for the substance. However, for cadmium chloride, a representative cadmium compound, developmental toxicity is suggested. Therefore, the substance was classified into Category 2 since the possibility of developmental toxicity of the substance cannot be ruled out. Refer also to cadmium chloride (CAS: 10108-64-2).
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, digestive system) Danger H370: Causes damage to organs (respiratory system, digestive system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
No data for the substance is available. However, as acute effects of cadmium compounds to humans, "chemical pneumonitis and oedema after inhalation exposure, and rapid onset with severe nausea, vomiting and abdominal pain after ingestion" are characteristic symptoms (EHC 134 (1992)). Based on the data, the substance was classified into Category 1 (respiratory system, alimentary system).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, kidney, bone) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, kidney, bone) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
For humans, there is a report that in a cadmium sulfide dye manufacturing factory, improvement of working condition resulted in a marked reduction in worker urine beta2-microglobulin levels (EHC 134 (1992)). In mice and hamsters, exposure to the substance (0.09 microg/L, 19h/day, 5 days/week, for 26 weeks) caused dose-dependent histopathological alterations, including proliferative and hyperplastic lesions in the respiratory tract (CaPSAR (1994)). Based on the data, target organs were considered to be bone and respiratory system. The effects on animals were observed at dose levels within the guidance value range for Category 1. In addition, as chronic effects of cadmium compounds to humans, "emphysema, renal dysfunction such as glomerular proteinuria, hypercalciuria, disturbances in rate of calcium to phosphate, hypophosphataemia, formation of renal stones, osteomalacia and osteoporosis" are characteristic (EHC 134 (1992)). Based on the information, the substance was classified into Category 1 (respiratory system, kidney, bone).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1 from its 48h-LC50 = 11 microg/L for Crustacea (Daphnia magna) (AQUIRE, 2010).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1 since its acute toxicity is Category 1 and the behavior in water is unknown from which it is a metal compound.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information