GHS Classification Result （Revision of the past classification result）

Chemical Name：Methyl bromide
CAS：74-83-9

Result：
ID: 21B3141
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Gas (GHS definition)
2 Flammable gases （including chemically unstable gases） Category 1 Danger H220: Extremely flammable gas P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P381: Eliminate all ignition sources if safe to do so.
P403: Store in a well-ventilated place. 		Classified into Category 1 since lower explosive limit is 10 vol% (ICSC (2000)). The substance is not classified as Flammable/Combustible gas in UNRTDG and a special provision sets forth that the substance is "combustible only under limited conditions" (UN1062 (not exceeding chloropicrin 2%)). Also, the substance is set forth as "Regarded as a special case depending on the regulatory purposes" according to the criteria for flammable/combustible gas in GHS documents.
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Classification not possible - - - - No data available. The substance is classified into Division 2.3 in UNRTDG (UN1062 (not exceeding chloropicrin 2%)).
5 Gases under pressure Low pressure liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. The substance is classified as "Low pressure liquefied gas" since boiling point is 4 degC (ICSC (1999)) and critical temperature is 194 degC (Merck (13th, 2001)) exceeding 65 degC.
6 Flammable liquids Not applicable - - - - Gas (GHS definition)
7 Flammable solids Not applicable - - - - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Gas (GHS definition)
9 Pyrophoric liquids Not applicable - - - - Gas (GHS definition)
10 Pyrophoric solids Not applicable - - - - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable - - - - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Gas (GHS definition)
13 Oxidizing liquids Not applicable - - - - Gas (GHS definition)
14 Oxidizing solids Not applicable - - - - Gas (GHS definition)
15 Organic peroxides Not applicable - - - - Gas (GHS definition)
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a LD50 value of 104,214 mg/kg for rats (SIDS (2002), Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008)), the substance was classified into Category 3.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a LC50 value of 781 ppm in a rat inhalation exposure test (gas) (EHC 166 (1995)), the substance was classified into Category 3.
1 Acute toxicity （Inhalation: Vapours） Not applicable - - - - Gas (GHS definition)
1 Acute toxicity （Inhalation: Dusts and mists） Not applicable - - - - Gas (GHS definition)
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Since there are a number of case reports describing skin irritation (ACGIH (7th, 2001), ATSDR (1992), SIDS (2002)), the substance was classified into Category 2. In a test where the substance (liquid) was applied to the back of rabbits, very slight erythema was observed in 1/6 animals within 24-hour, which disappeared within 48-hour (Test Data for Supporting Registration of Pesticides (1979)). Application of the substance to the back of rats led to the impairments to the epidermal cells and consequently necrosis (HSDB (2002)). In EU classification, the substance is classified into Xi; R38.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		In a rabbit test (exposure of gas), observed positive reactions in iris and cornea disappeared within 5 days (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008), SIDS (2002)). Based on the report, the substance was classified into Category 2B. As relevant information, the substance is classified as Xi; R36/37/38 in EU classification.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on positive results in micronucleus test by inhalation exposure to mice and rats for 2 weeks (SIDS (2002)) and mouse micronucleus test (ACGIH (2001)), the substance was classified into Category 2. As relevant information, there are reports of positive results from in vivo DNA damage test (SIDS (2002)). From in vitro mutagenicity tests, there are reports of positive reverse mutation test and chromosomal aberration test (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008)).
6 Carcinogenicity Not classified - - - - Based on the classifications of "A4" in ACGIH (ACGIH (2001)), "Group 3" in IARC (IARC (1999)) and "D" in EPA (EPA (1990)), the substance was classified as "Not classified". In 2-year inhalation (systemic exposure) tests in rats and mice, increased incidences of tumors were not observed in both sexes of either species, and there were no evidences of carcinogenicity of methyl bromide in F344/DuCrj (Fischer) rats or Crj:BDF1 mice (Results from Carcinogenicity tests (Ministry of Health, Labour and Welfare) (1989)).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In developmental toxicity tests in rabbits, increased incidence of anomalies (fused sternebrae, missing gallbladder or missing some lobe of lung) was observed in fetuses at dose levels in which maternal general toxicity was observed (SIDS (2002), IRIS (2002), Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008)). Based on the data, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, respiratory system, liver, kidney, digestive system) Danger H370: Causes damage to organs (nervous system, respiratory system, liver, kidney, digestive system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In human exposure cases, confusion, convulsion, coma, reduced vision, nausea, vomiting, renal failure, gastrointestinal disorder and hepatotoxic symptoms are reported (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008)). Based on this information, the substance was classified into Category 1 (nervous system, kidney, alimentary system, liver). In animals, dyspnea, ataxia, changes in the stomach (distention, redness, adhesions, ulceration) (SIDS (access on 6, 2009) and hepatic necrosis were observed following oral exposure in rats and mice (EHC No. 166 (1995)). In addition, decreased locomotor activity, decreased respiratory rate and pneumonia-like changes were observed at dose levels within the guidance value range for Category 1 (2500 ppmV/4h or less) following inhalation exposure in rats and mice (Test Data for Supporting Registration of Pesticides (1980)). Based on the data, the substance was classified into Category 1 (respiratory system). Although there is a report of congestion in the kidney and adrenal gland (Test Data for Supporting Registration of Pesticides (1980)), the details are unknown.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, heart, blood) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, heart, blood) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since effects on the cranial nerves are reported in humans (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008)), the substance was classified into Category 1 (nervous system). In a 13-week inhalation test in rats decreases in hematocrit, hemoglobin and erythrocyte count were observed at 87 ppm, which falls within the guidance value range for Category 2 (50 - 250 ppmV) (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008), NTP TR385 (1992)). In addition, in a 13-week oral dose test in rats, anemia was observed at 36 mg/kg/day, which falls within the guidance value range for Category 1 (less than 50 mg/kg/day) (IRIS (2002)). Based on the data, the substance was classified into Category 1 (blood). In a 3-week inhalation exposure test in rats (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008)), degeneration of myocardium, degeneration and necrosis in the testis, lethargy, tremor and paralysis of limbs were observed at 26.7 ppm and higher levels, which falls within the guidance value range for Category 1 (less than 50 ppm). Additionally, necrosis and fibrillization of myocardium are reported at 33.3 ppm and higher levels in another 3-week inhalation exposure test in rats (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008)). Based on the data, the substance was classified into Category 1 (heart). In 13 - 25 week oral dose tests (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 126 (2008)), chronic inflammation and fibrillization in the stomach were observed at 36 - 50 mg/kg/day, which fall within the guidance value range for Category 1 (less than 50 ppm), and lymphocytic infiltration in the glandular stomach and chronic inflammation in the esophagus were observed at 50 mg/kg/day. These data were not used for classification, since the effects were attributed to irritation of the substance. Findings of degeneration and necrosis in the testis noted in a 3-week inhalation exposure test in rats correspond to Category 2 of reproductive toxicity, and were not used for this classification.
10 Aspiration hazard Not applicable - - - - Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 from its 96h-LC50 = 0.7 mg/L for fish (Oryzias latipes) (Hazard Assessment Report (CERI, NITE), 2008).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (BOD degradation rate: 15, 17% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1991)).
12 Hazardous to the ozone layer Category 1 Warning H420: Harms public health and the environment by destroying zone in the upper atmosphere P502: Refer to manufacturer/supplier for information on recovery/recycling. This substance is listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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