GHS Classification Result (Revision of the past classification result)

Chemical Name:3,4-Dichloroaniline
CAS:95-76-1

Result:
ID: 21C0001
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - -
2 Flammable gases (including chemically unstable gases) - - - - -
3 Aerosols - - - - -
4 Oxidizing gases - - - - -
5 Gases under pressure - - - - -
6 Flammable liquids - - - - -
7 Flammable solids Classification not possible - - - - Classification is not possible since detailed data are not available though the information is available that the substance is "Combustible solid, Flammability 1" (NFPA (13th, 2006)).
8 Self-reactive substances and mixtures - - - - -
9 Pyrophoric liquids - - - - -
10 Pyrophoric solids - - - - -
11 Self-heating substances and mixtures - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - -
13 Oxidizing liquids - - - - -
14 Oxidizing solids - - - - -
15 Organic peroxides - - - - -
16 Corrosive to metals - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) - - - - -
1 Acute toxicity (Dermal) - - - - -
1 Acute toxicity (Inhalation: Gases) - - - - -
1 Acute toxicity (Inhalation: Vapours) - - - - -
1 Acute toxicity (Inhalation: Dusts and mists) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
LC50 values were >0.631 mg/L (OECD TG403) (EU-ARA (65, 2006)) and 3.3 mg/L (EU-ARA (65, 2006)) for rats exposed to the mist (aerosol) for 4-hour. Based on a definitive value of 3.3 mg/L, the substance was classified into Category 4.
2 Skin corrosion/irritation - - - - -
3 Serious eye damage/eye irritation - - - - -
4 Respiratory sensitization - - - - -
4 Skin sensitization - - - - -
5 Germ cell mutagenicity - - - - -
6 Carcinogenicity - - - - -
7 Reproductive toxicity - - - - -
8 Specific target organ toxicity - Single exposure Category 1 (blood system), Category 2 (nervous system) Danger
Warning
H370: Causes damage to organs (blood system)
H371: May cause damage to organs (nervous system)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
In a 24-hour dermal test with rats (dose levels: 130 - 1500 mg/kg), cyanosis was observed in all treated groups. In a 4-hour inhalation test with rats, increased methaemoglobin was noted at a dose level of 2.8 mg/L (mist because of the substance's saturated vapour pressure concentration of 0.055 mg/L) (EU-RAR 65 (2006)). In addition, there are reports that acute intoxication in humans and animals is indicated by the symptoms of cyanosis, fatigue, dyspnoea, and muscle weakness (PATTY (5th, 2001)) and that like other chloroanilines, the primary toxic effect of the substance is methaemoglobin formation and acute intoxication is indicated by the symptoms of methaemoglobinemia (cyanosis), fatigue, dyspnoea, and muscle weakness (EU-RAR (2006)). Based on the data, the substance was classified into Category 1 (blood system). Additionally, based on a report that clinical signs at doses of 500 - 800 mg/kg included paralysis of the hind extremities (EU-RAR 65 (2006)), the substance was classified into Category 2 (nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (Inhalation: blood system) Danger H372: Cause damage to organs through prolonged or repeated exposure (Inhalation: blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In a 2-week inhalation test with rats (6 hour/day, 5 days/week), increased methaemoglobin level and accumulation of hemosiderin in the spleen were observed at dose levels of 45 mg/m3 (90-day equivalence: 0.007 mg/L) and higher. In a 6-month oral test with rats, increased methaemoglobin level was reported at a dose level of 20 mg/kg which is within the guidance value range for Category 2 (EU-RAR 65 (2006)). Based on the results in the 2-week inhalation test with rats, the substance was classified into Category 1 (blood system) (inhalation).
10 Aspiration hazard - - - - -

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) - - - - -
11 Hazardous to the aquatic environment (Long-term) - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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