GHS Classification Result (Revision of the past classification result)

Chemical Name:Oxygen
CAS:7782-44-7

Result:
ID: 21C0005
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - -
2 Flammable gases (including chemically unstable gases) - - - - -
3 Aerosols - - - - -
4 Oxidizing gases - - - - -
5 Gases under pressure - - - - -
6 Flammable liquids - - - - -
7 Flammable solids - - - - -
8 Self-reactive substances and mixtures - - - - -
9 Pyrophoric liquids - - - - -
10 Pyrophoric solids - - - - -
11 Self-heating substances and mixtures - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - -
13 Oxidizing liquids - - - - -
14 Oxidizing solids - - - - -
15 Organic peroxides - - - - -
16 Corrosive to metals - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) - - - - -
1 Acute toxicity (Dermal) - - - - -
1 Acute toxicity (Inhalation: Gases) - - - - -
1 Acute toxicity (Inhalation: Vapours) - - - - -
1 Acute toxicity (Inhalation: Dusts and mists) - - - - -
2 Skin corrosion/irritation - - - - -
3 Serious eye damage/eye irritation - - - - -
4 Respiratory sensitization - - - - -
4 Skin sensitization - - - - -
5 Germ cell mutagenicity - - - - -
6 Carcinogenicity - - - - -
7 Reproductive toxicity Classification not possible - - - - When pregnant hamsters and rabbits were exposed to high-pressure oxygen or abnormally high concentration of oxygen, umbilical hernias, exencephaly, spina bifida and limb defects were produced in hamster fetuses (Teratogenic (12th, 2007)), and resorptions, malformations, anophthalmia, high mortality, runt (low incidence) were observed in rabbit fetuses (Birth Defects (3rd, 2000)). Since these tests were conducted by exposure to oxygen under high pressure and there is no data for sexual function and fertility, classification was not possible.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Rats exposed to 100% oxygen showed bronchiolar and vascular constriction after only 24-hour (PATTY (5th, 2001)). Rabbits exposed to 100% oxygen showed decreased lung capacity, decreased phospholipids (surfactant), and pulmonary edema after 24 - 96-hour (PATTY (5th, 2001)). In rats, a 12-hour exposure to 95% oxygen caused a decline in surfactant (PATTY (5th, 2001)). All reported effects appeared at dose levels exceeding the guidance value range. In humans, cough occurred after a <=4-hour exposure to 95% oxygen (PATTY (5th, 2001)). Cough occurred within 3-hour after exposure to 90 - 95% oxygen (HSDB (2007)). Based on the data, the substance was classified into Category 3 (respiratory tract irritation). Symptoms such as impairment of visual fields and visual acuity were reported in humans in association with hyperbaric oxygen (PATTY (5th, 2001)). Oxygen intoxication is notorious in the medical/submarine medical fields, however this intoxication occurs after atypical oxygen exposure under unusual situations, and is considered to be out of range of GHS Hazard Communication.
9 Specific target organ toxicity - Repeated exposure - - - - -
10 Aspiration hazard - - - - -

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) - - - - -
11 Hazardous to the aquatic environment (Long-term) - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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